Detalles de la búsqueda
1.
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.
Nature
; 531(7594): 381-5, 2016 Mar 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-26934220
2.
Drug Resistance Assessment Following Administration of Respiratory Syncytial Virus (RSV) Fusion Inhibitor Presatovir to Participants Experimentally Infected With RSV.
J Infect Dis
; 222(9): 1468-1477, 2020 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31971597
3.
Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors.
Antimicrob Agents Chemother
; 60(1): 316-22, 2016 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26503655
4.
Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile.
Antimicrob Agents Chemother
; 60(12): 7086-7097, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27645238
5.
Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing.
PLoS Pathog
; 10(4): e1004071, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24722454
6.
GS-5806 Inhibits a Broad Range of Respiratory Syncytial Virus Clinical Isolates by Blocking the Virus-Cell Fusion Process.
Antimicrob Agents Chemother
; 60(3): 1264-73, 2015 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-26666922
7.
GS-8374, a prototype phosphonate-containing inhibitor of HIV-1 protease, effectively inhibits protease mutants with amino acid insertions.
J Virol
; 88(6): 3586-90, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24371077
8.
Mutations in multiple domains of Gag drive the emergence of in vitro resistance to the phosphonate-containing HIV-1 protease inhibitor GS-8374.
J Virol
; 87(1): 454-63, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23097440
9.
Structure-activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers, part I: core region.
Bioorg Med Chem Lett
; 24(3): 989-94, 2014 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24411125
10.
Structure-activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers. Part II: P2/P3 region and discovery of cobicistat (GS-9350).
Bioorg Med Chem Lett
; 24(3): 995-9, 2014 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24412072
11.
Evaluation of the effect of cobicistat on the in vitro renal transport and cytotoxicity potential of tenofovir.
Antimicrob Agents Chemother
; 57(10): 4982-9, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23896476
12.
In vitro characterization of GS-8374, a novel phosphonate-containing inhibitor of HIV-1 protease with a favorable resistance profile.
Antimicrob Agents Chemother
; 55(4): 1366-76, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21245449
13.
Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV.
J Med Chem
; 64(8): 5001-5017, 2021 04 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-33835812
14.
HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein.
J Cell Biol
; 162(3): 425-34, 2003 Aug 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-12900394
15.
Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring.
J Mol Biol
; 363(3): 635-47, 2006 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-16979654
16.
Tenofovir alafenamide (TAF) does not deplete mitochondrial DNA in human T-cell lines at intracellular concentrations exceeding clinically relevant drug exposures.
Antiviral Res
; 140: 116-120, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28131805
17.
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.
J Med Chem
; 60(5): 1648-1661, 2017 03 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28124907
18.
Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study.
J Med Chem
; 58(4): 1630-43, 2015 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25574686
19.
Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells.
PLoS One
; 8(9): e74163, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24040198
20.
Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.
J Med Chem
; 54(15): 5498-507, 2011 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-21711054