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1.
Projections of Drug-Drug Interactions Caused by Time-Dependent Inhibitors of Cytochrome P450 1A2, 2B6, 2C8, 2C9, 2C19, and 2D6 Using In Vitro Data in Static and Dynamic Models.
Drug Metab Dispos
; 2024 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-38408867
2.
Production of active recombinant human aldehyde oxidase (AOX) in the baculovirus expression vector system (BEVS) and deployment in a pre-clinical fraction-of-control AOX compound exposure assay.
Protein Expr Purif
; 177: 105749, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32911062
3.
Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms.
Drug Metab Dispos
; 45(1): 1-7, 2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27784718
4.
Corrigendum to 'Production of active recombinant human aldehyde oxidase (AOX) in the baculovirus expression vector system (BEVS) and deployment in a pre-clinical fraction-of-control AOX compound exposure assay' [Protein Expr. Purif. 177 (2020) 105749].
Protein Expr Purif
; 179: 105769, 2021 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-33127220
5.
Undesired versus designed enzymatic cleavage of linkers for liver targeting.
Bioorg Med Chem Lett
; 24(4): 1144-7, 2014 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24461291
6.
Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance.
Drug Metab Dispos
; 40(7): 1441-8, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22522748
7.
Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs.
Drug Metab Dispos
; 40(3): 625-34, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22190693
8.
In vivo use of the P450 inactivator 1-aminobenzotriazole in the rat: varied dosing route to elucidate gut and liver contributions to first-pass and systemic clearance.
J Pharm Sci
; 95(6): 1334-41, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16625658
9.
Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design.
Eur J Med Chem
; 57: 441-8, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22840492
10.
Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.
J Med Chem
; 53(24): 8468-84, 2010 Dec 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-21105711
11.
Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.
J Med Chem
; 52(23): 7446-57, 2009 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-19775168
12.
Altered AZT (3'-azido-3'-deoxythymidine) glucuronidation kinetics in liver microsomes as an explanation for underprediction of in vivo clearance: comparison to hepatocytes and effect of incubation environment.
Drug Metab Dispos
; 33(11): 1621-7, 2005 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-16049128
13.
Flavin-containing monooxygenase activity in hepatocytes and microsomes: in vitro characterization and in vivo scaling of benzydamine clearance.
Drug Metab Dispos
; 30(10): 1087-93, 2002 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-12228184
14.
Novel CCR1 antagonists with improved metabolic stability.
Bioorg Med Chem Lett
; 14(9): 2175-9, 2004 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-15081003
15.
Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.
Science
; 302(5646): 875-8, 2003 Oct 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-14593182
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