Detalles de la búsqueda
1.
Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics.
Bioorg Med Chem Lett
; 27(4): 1062-1069, 2017 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28131713
2.
Data on the design and operation of drones by both individuals and teams.
Data Brief
; 36: 107008, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-33855142
3.
Calcitonin gene-related peptide receptor antagonism does not affect the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis.
J Pharmacol Exp Ther
; 328(2): 571-8, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18997059
4.
The prototype serotonin 5-HT 1B/1D agonist sumatriptan increases the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis.
J Cardiovasc Pharmacol
; 53(6): 474-9, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19430309
5.
Hemodynamic and cardiac neurotransmitter-releasing effects in conscious dogs of attention- and wake-promoting agents: a comparison of d-amphetamine, atomoxetine, modafinil, and a novel quinazolinone H3 inverse agonist.
J Cardiovasc Pharmacol
; 53(1): 52-9, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19129736
6.
Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure.
J Pharmacol Exp Ther
; 324(1): 322-30, 2008 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-17967939
7.
Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist.
J Med Chem
; 50(4): 807-19, 2007 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17249648
8.
Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation.
J Med Chem
; 49(24): 6954-7, 2006 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-17125248
9.
Characterization of an investigative safety pharmacology model to assess comprehensive cardiac function and structure in chronically instrumented conscious beagle dogs.
J Pharmacol Toxicol Methods
; 81: 107-14, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27166580
10.
NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles.
J Med Chem
; 47(8): 2089-96, 2004 Apr 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-15056006
11.
Benzodiazepines as potent and selective bradykinin B1 antagonists.
J Med Chem
; 46(10): 1803-6, 2003 May 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-12723943
12.
MK-0448, a specific Kv1.5 inhibitor: safety, pharmacokinetics, and pharmacodynamic electrophysiology in experimental animal models and humans.
Circ Arrhythm Electrophysiol
; 5(6): 1193-201, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23060423
13.
In vivo cardiac electrophysiologic and antiarrhythmic effects of an isoquinoline IKur blocker, ISQ-1, in rat, dog, and nonhuman primate.
J Cardiovasc Pharmacol
; 49(4): 236-45, 2007 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-17438409
14.
Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists.
Bioorg Med Chem Lett
; 17(14): 3997-4000, 2007 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17498948
15.
Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats.
Mol Pharmacol
; 69(3): 823-32, 2006 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-16301337
16.
Potent antagonists of the Kv1.5 potassium channel: synthesis and evaluation of analogous N,N-diisopropyl-2-(pyridine-3-yl)acetamides.
Bioorg Med Chem Lett
; 16(22): 5897-901, 2006 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16949818
17.
In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide.
J Pharmacol Exp Ther
; 315(3): 1362-7, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16157659
18.
In vivo canine cardiac electrophysiologic profile of 1,4-benzodiazepine IKs blockers.
J Cardiovasc Pharmacol
; 42(1): 105-12, 2003 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-12827034
19.
Non-peptide alphavbeta3 antagonists. Part 6: design and synthesis of alphavbeta3 antagonists containing a pyridone or pyrazinone central scaffold.
Bioorg Med Chem Lett
; 13(10): 1809-12, 2003 May 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-12729670
20.
Antiarrhythmic efficacy of combined I(Ks) and beta-adrenergic receptor blockade.
J Pharmacol Exp Ther
; 302(1): 283-9, 2002 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-12065728