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1.
Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910·Na (Rigosertib®), a phase III clinical stage anti-cancer agent.
Org Biomol Chem
; 11(12): 1964-77, 2013 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-23386308
2.
Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease.
Nat Commun
; 12(1): 4671, 2021 08 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34344863
3.
Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).
J Med Chem
; 57(3): 578-99, 2014 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24417566
4.
Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.
J Med Chem
; 56(13): 5562-86, 2013 Jul 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-23750455
5.
(Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.
J Med Chem
; 55(11): 5174-87, 2012 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-22587519
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