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1.
Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates.
Chem Soc Rev
; 53(4): 2099-2210, 2024 Feb 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38226865
2.
Examining the Scope of Deriving ß-Aryl Enones from Enol Silanes as Ketone Equivalents via Pd(II)-Mediated Sequential Dehydrosilylation and Arylation.
J Org Chem
; 88(11): 7256-7271, 2023 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37192466
3.
Orchestrating a ß-Hydride Elimination Pathway in Palladium(II)-Catalyzed Arylation/Alkenylation of Cyclopropanols Using Organoboron Reagents.
J Org Chem
; 87(7): 4508-4523, 2022 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35289619
4.
Electrophilic Hydrazination of Cyclopropanols Using Azodicarboxylates via Copper(II) Catalysis: An Umpolung Strategy to Access ß-Hydrazino Ketone Motifs.
J Org Chem
; 87(21): 14596-14608, 2022 11 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36190309
5.
Synthetic Access to α-Oxoketene Aminals by the Nucleophilic Addition of Enol Silane-Derived Palladium(II) Enolates to Carbodiimides.
J Org Chem
; 87(21): 14778-14792, 2022 11 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36285601
6.
Utility of Organoboron Reagents in Arylation of Cyclopropanols via Chelated Pd(II) Catalysis: Chemoselective Access to ß-Aryl Ketones.
J Org Chem
; 85(12): 7711-7727, 2020 06 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-32519863
7.
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.
ACS Med Chem Lett
; 15(2): 189-196, 2024 Feb 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-38352849
8.
Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design.
J Med Chem
; 64(19): 14046-14128, 2021 10 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34591488
9.
(Carbonyl)oxyalkyl linker-based amino acid prodrugs of the HIV-1 protease inhibitor atazanavir that enhance oral bioavailability and plasma trough concentration.
Eur J Med Chem
; 207: 112749, 2020 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33065417
10.
Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges.
J Med Chem
; 61(6): 2133-2165, 2018 03 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28731336
11.
Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir.
J Med Chem
; 61(9): 4176-4188, 2018 05 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29693401
12.
Design strategies in the prodrugs of HIV-1 protease inhibitors to improve the pharmaceutical properties.
Eur J Med Chem
; 139: 865-883, 2017 Oct 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-28865281
13.
Correction to "Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges".
J Med Chem
; 62(21): 10003, 2019 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31617718
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