Detalles de la búsqueda
1.
Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators requires high levels of intrahepatic HBV core protein.
Antimicrob Agents Chemother
; : e0042024, 2024 May 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38780261
2.
Assessing Pleiotropic Effects of a Mixed-Mode Perpetrator Drug, Rifampicin, by Multiple Endogenous Biomarkers in Dogs.
Drug Metab Dispos
; 52(3): 236-241, 2024 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38123963
3.
Lenacapavir: A Novel, Potent, and Selective First-in-Class Inhibitor of HIV-1 Capsid Function Exhibits Optimal Pharmacokinetic Properties for a Long-Acting Injectable Antiretroviral Agent.
Mol Pharm
; 20(12): 6213-6225, 2023 Dec 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-37917742
4.
18O-Enabled High-Throughput Acyl Glucuronide Stability Assay.
Chem Res Toxicol
; 35(8): 1400-1409, 2022 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35833852
5.
Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection.
Xenobiotica
; 52(9-11): 973-985, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36546430
6.
Human pharmacokinetics prediction with an in vitro-in vivo correction factor approach and in vitro drug-drug interaction profile of bictegravir, a potent integrase-strand transfer inhibitor component in approved biktarvy® for the treatment of HIV-1 infection.
Xenobiotica
; 52(12): 1020-1030, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36701274
7.
Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells.
Antimicrob Agents Chemother
; 65(9): e0060221, 2021 08 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34125594
8.
Characterization of Seasonal Pharmacokinetic Variability in Woodchucks.
Drug Metab Dispos
; 48(11): 1199-1209, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32892154
9.
Organic Anion-Transporting Polypeptide Genes Are Not Induced by the Pregnane X Receptor Activator Rifampin: Studies in Hepatocytes In Vitro and in Monkeys In Vivo.
Drug Metab Dispos
; 47(12): 1433-1442, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31582395
10.
Pharmacokinetics and Disposition of Momelotinib Revealed a Disproportionate Human Metabolite-Resolution for Clinical Development.
Drug Metab Dispos
; 46(3): 237-247, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29311136
11.
Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function.
J Immunol
; 196(2): 573-85, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26673135
12.
Drug disposition model of radiolabeled etelcalcetide in patients with chronic kidney disease and secondary hyperparathyroidism on hemodialysis.
J Pharmacokinet Pharmacodyn
; 44(1): 43-53, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28063122
13.
Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide).
Drug Metab Dispos
; 44(8): 1319-31, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26895981
14.
Nonclinical Safety Profile of Etelcalcetide, a Novel Peptide Calcimimetic for the Treatment of Secondary Hyperparathyroidism.
Int J Toxicol
; 35(3): 294-308, 2016 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26941242
15.
Critical Cysteine Residues in Both the Calcium-Sensing Receptor and the Allosteric Activator AMG 416 Underlie the Mechanism of Action.
Mol Pharmacol
; 88(5): 853-65, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26290606
16.
The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors.
Bioorg Med Chem Lett
; 25(19): 4136-42, 2015 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26298499
17.
Comparison of information-dependent acquisition, SWATH, and MS(All) techniques in metabolite identification study employing ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.
Anal Chem
; 86(2): 1202-9, 2014 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-24383719
18.
Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
Bioorg Med Chem Lett
; 24(24): 5630-5634, 2014 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25466188
19.
Accelerated and Biopredictive In Vitro Release Testing Strategy for Single Agent and Combination Long-Acting Injectables.
J Pharm Sci
; 113(7): 1885-1897, 2024 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-38369022
20.
Pharmacokinetics, Disposition, and Biotransformation of [14C]Lenacapavir, a Novel, First-in-Class, Selective Inhibitor of HIV-1 Capsid Function, in Healthy Participants Following a Single Intravenous Infusion.
Clin Pharmacokinet
; 63(2): 241-253, 2024 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38236562