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1.
Comprehensive gene profiling of the metabolic landscape of humanized livers in mice.
J Hepatol
; 80(4): 622-633, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38049085
2.
TNF receptor-related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF-κB-inducing kinase-mediated hepatocyte transdifferentiation.
Hepatology
; 77(2): 395-410, 2023 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34995376
3.
In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells.
Chem Res Toxicol
; 37(5): 671-674, 2024 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38626399
4.
HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes.
Biochem Biophys Res Commun
; 663: 132-141, 2023 06 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-37121123
5.
The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers.
Drug Metab Dispos
; 51(4): 480-491, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36623885
6.
Pharmacokinetic Models Scaled-up from Humanized-liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N-Demethylated Metabolites i n Pediatric Patients Genotyped for Cytochrome P450 2D6.
Drug Metab Dispos
; 2023 Oct 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-37879849
7.
Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css-MRTpo method and chimeric mice with humanised livers.
Xenobiotica
; 53(8-9): 523-535, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37938160
8.
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation.
Xenobiotica
; 53(6-7): 465-473, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37800661
9.
Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes.
Proc Natl Acad Sci U S A
; 117(3): 1678-1688, 2020 01 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31915293
10.
Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production.
Gastroenterology
; 160(5): 1741-1754.e16, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33346004
11.
Bovine ß-lactoglobulin-induced passive systemic anaphylaxis model using humanized NOG hIL-3/hGM-CSF transgenic mice.
Int Immunol
; 33(3): 183-189, 2021 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33027513
12.
Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes.
Xenobiotica
; 52(3): 229-239, 2022 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-35416115
13.
Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets.
Xenobiotica
; 52(6): 613-624, 2022 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-36148579
14.
Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model.
Chem Res Toxicol
; 34(2): 522-528, 2021 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33198470
15.
Novel hepatitis B virus infection mouse model using herpes simplex virus type 1 thymidine kinase transgenic mice.
J Gastroenterol Hepatol
; 36(3): 782-789, 2021 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-32515517
16.
Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes.
Xenobiotica
; 51(5): 582-589, 2021 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-33455497
17.
UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers.
Xenobiotica
; 51(10): 1146-1154, 2021 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-34423713
18.
Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models.
Xenobiotica
; 51(6): 636-642, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-33781181
19.
Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling.
Xenobiotica
; 51(3): 316-323, 2021 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-33179995
20.
Highly efficient induction of primate iPS cells by combining RNA transfection and chemical compounds.
Genes Cells
; 24(7): 473-484, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-31099158