Detalles de la búsqueda
1.
A 20-Year Research Overview: Quantitative Prediction of Hepatic Clearance Using the In Vitro-In Vivo Extrapolation Approach Based on Physiologically Based Pharmacokinetic Modeling and Extended Clearance Concept.
Drug Metab Dispos
; 51(9): 1067-1076, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37407092
2.
Predicting In Vivo Target Occupancy (TO) Profiles via Physiologically Based Pharmacokinetic-TO Modeling of Warfarin Pharmacokinetics in Blood: Importance of Low Dose Data and Prediction of Stereoselective Target Interactions.
Drug Metab Dispos
; 51(9): 1145-1156, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36914276
3.
Experimental and Modeling Evidence Supporting the Trans-Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A.
Drug Metab Dispos
; 50(5): 541-551, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35241487
4.
Frequency of null genotypes of glutathione S-transferase M1 and T1 in Japanese patients with drug-induced liver injury.
Hepatol Res
; 52(10): 882-887, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-35834381
5.
Post-translational regulation of the major drug transporters in the families of organic anion transporters and organic anion-transporting polypeptides.
J Biol Chem
; 295(50): 17349-17364, 2020 12 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33051208
6.
Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target Occupancy.
Drug Metab Dispos
; 49(4): 298-304, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33558262
7.
Practical Synthesis of [18F]Pitavastatin and Evaluation of Hepatobiliary Transport Activity in Rats by Positron Emission Tomography.
Mol Pharm
; 17(6): 1884-1898, 2020 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32271581
8.
Extrapolation of In Vivo Hepatic Clearance from In Vitro Uptake Clearance by Suspended Human Hepatocytes for Anionic Drugs with High Binding to Human Albumin: Improvement of In Vitro-to-In Vivo Extrapolation by Considering the "Albumin-Mediated" Hepatic Uptake Mechanism on the Basis of the "Facilitated-Dissociation Model".
Drug Metab Dispos
; 47(2): 94-103, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30504137
9.
Correction to: Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers.
Pharm Res
; 36(4): 55, 2019 02 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30790061
10.
Evaluation of Alteration in Hepatic and Intestinal BCRP Function In Vivo from ABCG2 c.421C>A Polymorphism Based on PBPK Analysis of Rosuvastatin.
Drug Metab Dispos
; 46(5): 749-757, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29440178
11.
Organic Anion Transporting Polypeptide 1a4 is Responsible for the Hepatic Uptake of Cardiac Glycosides in Mice.
Drug Metab Dispos
; 46(5): 652-657, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29348124
12.
Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling.
Drug Metab Dispos
; 46(7): 924-933, 2018 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-29712725
13.
Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics.
Drug Metab Dispos
; 46(5): 740-748, 2018 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-29475833
14.
The Phenomenon of Albumin-Mediated Hepatic Uptake of Organic Anion Transport Polypeptide Substrates: Prediction of the In Vivo Uptake Clearance from the In Vitro Uptake by Isolated Hepatocytes Using a Facilitated-Dissociation Model.
Drug Metab Dispos
; 46(3): 259-267, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29298773
15.
A Clinical Quantitative Evaluation of Hepatobiliary Transport of [11C]Dehydropravastatin in Humans Using Positron Emission Tomography.
Drug Metab Dispos
; 46(5): 719-728, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29555827
16.
Relative Activity Factor (RAF)-Based Scaling of Uptake Clearance Mediated by Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 in Human Hepatocytes.
Mol Pharm
; 15(6): 2277-2288, 2018 06 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29746136
17.
In Silico Prediction of Major Clearance Pathways of Drugs among 9 Routes with Two-Step Support Vector Machines.
Pharm Res
; 35(10): 197, 2018 Aug 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-30143865
18.
Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers.
Pharm Res
; 35(7): 138, 2018 05 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29748935
19.
Phase 0, including microdosing approaches: Applying the Three Rs and increasing the efficiency of human drug development.
Altern Lab Anim
; 46(6): 335-346, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30657329
20.
Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins.
Drug Metab Dispos
; 45(7): 779-789, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28468836