Detalles de la búsqueda
1.
Free Drug Theory - No Longer Just a Hypothesis?
Pharm Res
; 39(2): 213-222, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-35112229
2.
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development.
Pharm Res
; 39(7): 1321-1341, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-35411506
3.
In Vivo Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders.
Bioconjug Chem
; 32(2): 279-289, 2021 02 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-33523652
4.
Drug Distribution into Peripheral Nerve.
J Pharmacol Exp Ther
; 365(2): 336-345, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29511033
5.
Correlation between Membrane Protein Expression Levels and Transcellular Transport Activity for Breast Cancer Resistance Protein.
Drug Metab Dispos
; 45(5): 449-456, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28209803
6.
Examining the Uptake of Central Nervous System Drugs and Candidates across the Blood-Brain Barrier.
J Pharmacol Exp Ther
; 358(2): 294-305, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27194478
7.
Integrating in Silico and in Vitro Approaches To Predict Drug Accessibility to the Central Nervous System.
Mol Pharm
; 13(5): 1540-50, 2016 05 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27015243
8.
In vitro, in vivo and in silico models of drug distribution into the brain.
J Pharmacokinet Pharmacodyn
; 40(3): 301-14, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23404394
9.
The GSK Bioanalytical Hub model in bioanalysis: maximizing the synergies of co-locating various platforms in support of regulated and nonregulated study end points.
Bioanalysis
; 15(3): 127-132, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36916633
10.
2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Endogenous Compounds, Small Molecules, Complex Methods, Regulated Mass Spec of Large Molecules, Small Molecule, PoC & Part 1B - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine).
Bioanalysis
; 14(9): 505-580, 2022 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-35578993
11.
2020 White Paper on Recent Issues in Bioanalysis: BMV of Hybrid Assays, Acoustic MS, HRMS, Data Integrity, Endogenous Compounds, Microsampling and Microbiome (Part 1 - Recommendations on Industry/Regulators Consensus on BMV of Biotherapeutics by LCMS, Advanced Application in Hybrid Assays, Regulatory Challenges in Mass Spec, Innovation in Small Molecules, Peptides and Oligos).
Bioanalysis
; 13(4): 203-238, 2021 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-33470871
12.
Assessment of the blood-brain barrier in CNS drug discovery.
Neurobiol Dis
; 37(1): 33-7, 2010 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19664709
13.
Perspectives on gender parity in bioanalysis: an interview with Scott Summerfield.
Bioanalysis
; 11(7): 675-676, 2019 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-30997820
14.
The importance of evaluating the chemical structures and strategies to avoid pitfalls in quantitative bioanalysis.
Bioanalysis
; 11(2): 85-101, 2019 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-30475061
15.
Incurred sample reanalysis at GSK: what have we learned?
Bioanalysis
; 10(21): 1755-1766, 2018 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30325209
16.
Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems.
Drug Discov Today
; 23(7): 1357-1372, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29548981
17.
Rapid Bioavailability and Disposition protocol: A novel higher throughput approach to assess pharmacokinetics and steady-state brain distribution with reduced animal usage.
Eur J Pharm Sci
; 122: 13-21, 2018 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29857045
18.
2018 White Paper on Recent Issues in Bioanalysis: 'A global bioanalytical community perspective on last decade of incurred samples reanalysis (ISR)' (Part 1 - small molecule regulated bioanalysis, small molecule biomarkers, peptides & oligonucleotide bioanalysis).
Bioanalysis
; 10(22): 1781-1801, 2018 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30488725
19.
Toward best practices in data processing and analysis for intact biotherapeutics by MS in quantitative bioanalysis.
Bioanalysis
; 9(23): 1883-1893, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-29171758
20.
2017 White Paper on recent issues in bioanalysis: aren't BMV guidance/guidelines 'Scientific'? (Part 1 - LCMS: small molecules, peptides and small molecule biomarkers).
Bioanalysis
; 9(22): 1807-1825, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-29148835