Detalles de la búsqueda
1.
Therapeutic potential of the novel Bcl-2/Bcl-XL dual inhibitor, APG1252, alone or in combination against non-small cell lung cancer.
Mol Carcinog
; 61(11): 1031-1042, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36066010
2.
The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition.
Pharmacol Res
; 175: 105998, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34826601
3.
Rictor, an essential component of mTOR complex 2, undergoes caspase-mediated cleavage during apoptosis induced by multiple stimuli.
Apoptosis
; 26(5-6): 338-347, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33905036
4.
ERK inhibition effectively overcomes acquired resistance of epidermal growth factor receptor-mutant non-small cell lung cancer cells to osimertinib.
Cancer
; 126(6): 1339-1350, 2020 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31821539
5.
Overcoming acquired resistance of epidermal growth factor receptor-mutant non-small cell lung cancer cells to osimertinib by combining osimertinib with the histone deacetylase inhibitor panobinostat (LBH589).
Cancer
; 126(9): 2024-2033, 2020 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31999837
6.
MEK or ERK inhibition effectively abrogates emergence of acquired osimertinib resistance in the treatment of epidermal growth factor receptor-mutant lung cancers.
Cancer
; 126(16): 3788-3799, 2020 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32497272
7.
Tumour necrosis factor-α-induced protein 8-like 2 is a novel regulator of proliferation, migration, and invasion in human rectal adenocarcinoma cells.
J Cell Mol Med
; 23(3): 1698-1713, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30637920
8.
Expression of Death Receptor 4 Is Positively Regulated by MEK/ERK/AP-1 Signaling and Suppressed upon MEK Inhibition.
J Biol Chem
; 291(41): 21694-21702, 2016 Oct 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27576686
9.
DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion.
Cell Commun Signal
; 15(1): 18, 2017 05 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28482915
10.
Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.
J Biol Chem
; 290(22): 14120-9, 2015 May 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-25897075
11.
Correction: Proteasome inhibitor PS-341 (bortezomib) induces calpain-dependent IκBα degradation.
J Biol Chem
; 295(26): 8869, 2020 Jun 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32591445
12.
Correction: Expression of death receptor 4 is positively regulated by MEK/ERK/AP-1 signaling and suppressed upon MEK inhibition.
J Biol Chem
; 295(26): 8871, 2020 Jun 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32591447
13.
Correction: Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling.
J Biol Chem
; 295(26): 8870, 2020 Jun 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32591446
14.
Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer.
J Transl Med
; 14(1): 111, 2016 05 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-27142472
15.
MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells.
Blood
; 123(21): 3269-76, 2014 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-24713927
16.
Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation.
J Biol Chem
; 288(19): 13215-24, 2013 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-23536185
17.
Phase 1 and pharmacokinetic study of everolimus in combination with cetuximab and carboplatin for recurrent/metastatic squamous cell carcinoma of the head and neck.
Cancer
; 120(24): 3940-51, 2014 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25103371
18.
Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.
Nat Cell Biol
; 9(10): 1199-207, 2007 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-17891137
19.
[Quantitative detection of hydroxyl radical generated in quartz powder/phosphate buffer solution system by fluorescence spectrophotometry].
Guang Pu Xue Yu Guang Pu Fen Xi
; 34(7): 1886-9, 2014 Jul.
Artículo
en Zh
| MEDLINE | ID: mdl-25269301
20.
DNA topoisomerase II inhibition potentiates osimertinib's therapeutic efficacy in EGFR-mutant non-small cell lung cancer models.
J Clin Invest
; 134(10)2024 Mar 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38451729