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1.
Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor.
Bioorg Med Chem Lett
; 27(11): 2634-2640, 2017 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28416131
2.
The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-α-chloro-2'-ß-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors.
Bioorg Med Chem Lett
; 27(18): 4323-4330, 2017 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28835346
3.
Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase.
Bioorg Med Chem Lett
; 26(18): 4536-4541, 2016 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27520942
4.
Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease.
Bioorg Med Chem Lett
; 25(18): 3984-91, 2015 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26231161
5.
Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320.
Bioorg Med Chem Lett
; 25(22): 5427-36, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26410074
6.
Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.
Bioorg Med Chem Lett
; 24(18): 4444-4449, 2014 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25155387
7.
Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states.
Org Biomol Chem
; 10(17): 3448-54, 2012 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-22434259
8.
Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors.
Bioorg Med Chem Lett
; 18(18): 5095-100, 2008 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18722116
9.
Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors.
Bioorg Med Chem Lett
; 18(23): 6189-93, 2008 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18954982
10.
Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350.
Bioorg Med Chem Lett
; 18(17): 4853-8, 2008 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18678486
11.
Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase.
J Med Chem
; 48(6): 1930-40, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771437
12.
Design of HIV-1 protease inhibitors active on multidrug-resistant virus.
J Med Chem
; 48(6): 1965-73, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771440
13.
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.
J Med Chem
; 48(6): 1813-22, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771427
14.
Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.
Future Med Chem
; 7(13): 1675-700, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26424162
15.
Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors.
Bioorg Med Chem Lett
; 17(7): 1843-9, 2007 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17289388
16.
Binding-site identification and genotypic profiling of hepatitis C virus polymerase inhibitors.
J Virol
; 81(13): 6909-19, 2007 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-17459932
17.
TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates.
Antimicrob Agents Chemother
; 49(6): 2314-21, 2005 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15917527
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