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1.
An S-warfarin and AZD1981 interaction: in vitro and clinical pilot data suggest the N-deacetylated amino acid metabolite as the primary perpetrator.
Br J Clin Pharmacol
; 83(2): 381-392, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27558866
2.
Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG.
Drug Metab Dispos
; 44(4): 527-33, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26851239
3.
Predicting metabolic clearance for drugs that are actively transported into hepatocytes: incubational binding as a consequence of in vitro hepatocyte concentration is a key factor.
Drug Metab Dispos
; 41(4): 836-43, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23364509
4.
AZD9567 versus prednisolone in patients with active rheumatoid arthritis: A phase IIa, randomized, double-blind, efficacy, and safety study.
Clin Transl Sci
; 16(12): 2494-2506, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37873558
5.
Optimized experimental design for the estimation of enzyme kinetic parameters: an experimental evaluation.
Drug Metab Dispos
; 40(12): 2273-9, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22942316
6.
AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2.
J Med Chem
; 64(18): 13807-13829, 2021 09 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-34464130
7.
Effects of a selective glucocorticoid receptor modulator (AZD9567) versus prednisolone in healthy volunteers: two phase 1, single-blind, randomised controlled trials.
Lancet Rheumatol
; 2(1): e31-e41, 2020 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-38258274
8.
Dual Role For A MEK Inhibitor As A Modulator Of Inflammation And Host Defense Mechanisms With Potential Therapeutic Application In COPD.
Int J Chron Obstruct Pulmon Dis
; 14: 2611-2624, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-32063702
9.
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
J Med Chem
; 61(5): 1785-1799, 2018 03 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29424542
10.
Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds.
J Pharm Sci
; 105(2): 838-845, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26178700
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