Detalles de la búsqueda
1.
Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.
Bioorg Med Chem Lett
; 36: 127823, 2021 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33508465
2.
The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.
Bioorg Med Chem Lett
; 28(9): 1550-1557, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29631960
3.
Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.
Antimicrob Agents Chemother
; 60(7): 3956-69, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27090171
4.
Inhibitors of HIV-1 attachment: The discovery and structure-activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore.
Bioorg Med Chem Lett
; 26(1): 160-7, 2016 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26584882
5.
Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.
Bioorg Med Chem Lett
; 26(8): 1925-30, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26988305
6.
C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.
Bioorg Med Chem
; 24(8): 1757-70, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26968652
7.
The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.
J Med Chem
; 65(18): 11927-11948, 2022 09 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36044257
8.
Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176).
J Med Chem
; 61(16): 7289-7313, 2018 08 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-30067361
9.
A concise total synthesis of (-)-cylindricine C through a stereoselective intramolecular aza-[3 + 3] annulation strategy.
Org Lett
; 8(4): 777-80, 2006 Feb 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-16468765
10.
A Lewis acid-catalyzed formal [3 + 3] cycloaddition of alpha,beta-unsaturated aldehydes with 4-hydroxy-2-pyrone, diketones, and vinylogous esters.
Org Lett
; 8(2): 191-3, 2006 Jan 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-16408872
11.
Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.
ACS Med Chem Lett
; 7(6): 568-72, 2016 Jun 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27326328
12.
Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 12. Structure-activity relationships associated with 4-fluoro-6-azaindole derivatives leading to the identification of 1-(4-benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl-1h-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-585248).
J Med Chem
; 56(4): 1656-69, 2013 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-23360431
13.
An N-acyliminium cyclization approach to a total synthesis of (+)-cylindricine C.
J Org Chem
; 70(10): 3898-902, 2005 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-15876077
14.
An efficient assembly of heterobenzazepine ring systems utilizing an intramolecular palladium-catalyzed cycloamination.
J Org Chem
; 68(2): 644-7, 2003 Jan 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-12530903
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