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1.
A Glutamate N-Methyl-d-Aspartate (NMDA) Receptor Subunit 2B-Selective Inhibitor of NMDA Receptor Function with Enhanced Potency at Acidic pH and Oral Bioavailability for Clinical Use.
J Pharmacol Exp Ther
; 379(1): 41-52, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34493631
2.
Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model.
ACS Chem Neurosci
; 14(5): 917-935, 2023 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36779874
3.
Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.
J Med Chem
; 65(5): 4058-4084, 2022 03 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35179893
4.
Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings.
ACS Med Chem Lett
; 12(10): 1605-1612, 2021 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34676043
5.
Small molecule and peptide-based CXCR4 modulators as therapeutic agents. A patent review for the period from 2010 to 2018.
Expert Opin Ther Pat
; 30(2): 87-101, 2020 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-31854208
6.
Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.
Bioorg Med Chem
; 17(17): 6463-80, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19648014
7.
Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors.
Nat Commun
; 10(1): 321, 2019 01 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-30659174
8.
An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups.
Elife
; 72018 05 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-29792594
9.
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties.
J Med Chem
; 61(16): 7168-7188, 2018 08 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-30052039
10.
Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties.
J Med Chem
; 61(3): 946-979, 2018 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29350534
11.
Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists.
ACS Med Chem Lett
; 9(1): 17-22, 2018 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29348805
12.
Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains.
ACS Med Chem Lett
; 9(2): 89-93, 2018 Feb 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29456793
13.
Discovery of N-Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties.
ACS Med Chem Lett
; 9(5): 446-451, 2018 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29795757
14.
CCR5 receptor antagonists in preclinical to phase II clinical development for treatment of HIV.
Expert Opin Investig Drugs
; 25(12): 1377-1392, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27791451
15.
Context-dependent GluN2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects.
Neuron
; 85(6): 1305-1318, 2015 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-25728572
16.
Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.
J Med Chem
; 51(18): 5506-21, 2008 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-18800760
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