Detalles de la búsqueda
1.
An Open-Label Study of the Impact of Hepatic Impairment on the Pharmacokinetics and Safety of Single Oral and Intravenous Doses of Omadacycline.
Antimicrob Agents Chemother
; 64(11)2020 10 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-32839218
2.
Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study of the Effects of Omadacycline on QT/QTc Intervals in Healthy Subjects.
Antimicrob Agents Chemother
; 63(10)2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31405867
3.
In Vitro and In Vivo Activity of Omadacycline against Two Biothreat Pathogens, Bacillus anthracis and Yersinia pestis.
Antimicrob Agents Chemother
; 61(5)2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28223382
4.
Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline following a Single Intravenous or Oral Dose of 14C-Omadacycline in Rats.
Antimicrob Agents Chemother
; 61(1)2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27821446
5.
Comparison of Omadacycline and Tigecycline Pharmacokinetics in the Plasma, Epithelial Lining Fluid, and Alveolar Cells of Healthy Adult Subjects.
Antimicrob Agents Chemother
; 61(9)2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28696233
6.
Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline.
Xenobiotica
; 47(8): 682-696, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-27499331
7.
In Vitro and In Vivo Assessments of Cardiovascular Effects with Omadacycline.
Antimicrob Agents Chemother
; 60(9): 5247-53, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27324778
8.
Randomized, Open-Label Study of the Pharmacokinetics and Safety of Oral and Intravenous Administration of Omadacycline to Healthy Subjects.
Antimicrob Agents Chemother
; 60(12): 7431-7435, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27736760
9.
Discovery, pharmacology, and clinical profile of omadacycline, a novel aminomethylcycline antibiotic.
Bioorg Med Chem
; 24(24): 6409-6419, 2016 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27469981
10.
Correction for Kovacs et al., "An Open-Label Study of the Impact of Hepatic Impairment on the Pharmacokinetics and Safety of Single Oral and Intravenous Doses of Omadacycline".
Antimicrob Agents Chemother
; 65(1)2020 Dec 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-33328319
11.
Structure-activity relationship of the aminomethylcyclines and the discovery of omadacycline.
Antimicrob Agents Chemother
; 59(11): 7044-53, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26349824
12.
A randomized, evaluator-blind, phase 2 study comparing the safety and efficacy of omadacycline to those of linezolid for treatment of complicated skin and skin structure infections.
Antimicrob Agents Chemother
; 56(11): 5650-4, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22908151
13.
Sub-growth-inhibitory concentrations of omadacycline inhibit Staphylococcus aureus haemolytic activity in vitro.
JAC Antimicrob Resist
; 4(1): dlab190, 2022 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-34988444
14.
Activity of omadacycline in vitro against Clostridioides difficile and preliminary efficacy assessment in a hamster model of C. difficile-associated diarrhoea.
J Glob Antimicrob Resist
; 30: 96-99, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35500838
15.
Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity.
Front Med (Lausanne)
; 9: 1033980, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36569144
16.
Antibacterial Mechanisms and Efficacy of Sarecycline in Animal Models of Infection and Inflammation.
Antibiotics (Basel)
; 10(4)2021 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33920812
17.
Small molecule inhibitors of LcrF, a Yersinia pseudotuberculosis transcription factor, attenuate virulence and limit infection in a murine pneumonia model.
Infect Immun
; 78(11): 4683-90, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20823209
18.
N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stability.
Bioorg Med Chem Lett
; 20(11): 3380-3, 2010 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20434913
19.
Effect of Food on the Bioavailability of Omadacycline in Healthy Participants.
J Clin Pharmacol
; 57(3): 321-327, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-27539539
20.
N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: novel antivirulence agents.
J Med Chem
; 52(18): 5626-34, 2009 Sep 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-19708663