Detalles de la búsqueda
1.
A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery.
Drug Metab Dispos
; 48(11): 1147-1160, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32943412
2.
Human Alzheimer's disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aß plaque pathology.
J Neuroinflammation
; 15(1): 256, 2018 Sep 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30189875
3.
Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity.
Hum Mol Genet
; 21(1): 163-74, 2012 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21972245
4.
A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies.
Toxicol Sci
; 188(1): 4-16, 2022 06 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35404422
5.
Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine.
J Neurochem
; 116(1): 82-92, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21054384
6.
Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats.
Toxicol Sci
; 181(2): 148-159, 2021 05 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-33837425
7.
Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety Liabilities.
Toxicol Sci
; 175(1): 98-112, 2020 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32119089
8.
Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline.
Toxicol Sci
; 177(1): 121-139, 2020 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32559289
9.
Author Correction: The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease.
Sci Rep
; 10(1): 8374, 2020 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32409700
10.
Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury.
Toxicol Sci
; 177(1): 281-299, 2020 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32559301
11.
AhR Activation in Pharmaceutical Development: Applying Liver Gene Expression Biomarker Thresholds to Identify Doses Associated With Tumorigenic Risks in Rats.
Toxicol Sci
; 171(1): 46-55, 2019 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31127949
12.
Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity.
Toxicol Sci
; 170(1): 180-198, 2019 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30903168
13.
Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease.
Neurobiol Aging
; 64: 92-106, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29353102
14.
Comparative transcriptomics of choroid plexus in Alzheimer's disease, frontotemporal dementia and Huntington's disease: implications for CSF homeostasis.
Fluids Barriers CNS
; 15(1): 18, 2018 May 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-29848382
15.
Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.
Mol Cell Biol
; 23(11): 3884-96, 2003 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-12748290
16.
Transcriptional Profiling of Cholinergic Neurons From Basal Forebrain Identifies Changes in Expression of Genes Between Sleep and Wake.
Sleep
; 40(6)2017 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28419375
17.
The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease.
Sci Rep
; 7(1): 17193, 2017 12 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29222421
18.
Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation.
Sleep
; 37(10): 1589-600, 2014 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25197809
19.
Analysis of target genes regulated by chronic electroconvulsive therapy reveals role for Fzd6 in depression.
Biol Psychiatry
; 71(1): 51-8, 2012 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21937024
20.
Transcriptional architecture of the primate neocortex.
Neuron
; 73(6): 1083-99, 2012 Mar 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-22445337