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1.
Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target.
Proc Natl Acad Sci U S A
; 109(42): 16823-8, 2012 Oct 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-23035243
2.
Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase.
ACS Chem Biol
; 17(7): 1691-1702, 2022 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35715223
3.
Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities.
Eur J Med Chem
; 195: 112263, 2020 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32294614
4.
Particular interaction between pyrimethamine derivatives and quadruple mutant type dihydrofolate reductase of Plasmodium falciparum: CoMFA and quantum chemical calculations studies.
J Enzyme Inhib Med Chem
; 24(2): 471-9, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-18608776
5.
Characterization of Plasmodium knowlesi dihydrofolate reductase-thymidylate synthase and sensitivity to antifolates.
Parasitol Int
; 67(6): 787-792, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30114522
6.
Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance.
ACS Med Chem Lett
; 9(12): 1235-1240, 2018 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30613332
7.
Novel antifolate resistant mutations of Plasmodium falciparum dihydrofolate reductase selected in Escherichia coli.
Mol Biochem Parasitol
; 120(1): 61-72, 2002 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-11849706
8.
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.
J Med Chem
; 45(6): 1244-52, 2002 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-11881993
9.
Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.
J Med Chem
; 47(3): 673-80, 2004 Jan 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-14736247
10.
Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.
Antimicrob Agents Chemother
; 50(11): 3631-7, 2006 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-16954316
11.
Crystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance.
Proc Natl Acad Sci U S A
; 102(37): 13046-51, 2005 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-16135570
12.
Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.
Anal Chem
; 77(5): 1222-7, 2005 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15732900
13.
Ecdysteroids from a Zoanthus sp.
J Nat Prod
; 65(8): 1194-7, 2002 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-12193031
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