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1.
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part I.
Bioorg Med Chem
; 23(10): 2568-78, 2015 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25862209
2.
Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists.
Bioorg Med Chem
; 20(1): 422-34, 2012 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22094279
3.
17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors.
Bioorg Med Chem
; 19(5): 1751-70, 2011 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21316976
4.
17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors.
Bioorg Med Chem
; 19(7): 2428-42, 2011 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21429754
5.
Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.
Bioorg Med Chem
; 19(21): 6383-99, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21978946
6.
Highly enantioselective reformatsky reaction of ketones: chelation-assisted enantioface discrimination.
Org Lett
; 4(18): 3051-4, 2002 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-12201714
7.
Total Synthesis of (-)-Bafilomycin A1 : Application of Diastereoselective Crotylboration and Methyl Ketone Aldol Reactions.
Angew Chem Int Ed Engl
; 38(11): 1652-1655, 1999 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29710989
8.
Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats.
J Steroid Biochem Mol Biol
; 134: 80-91, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23146910
9.
Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys.
J Steroid Biochem Mol Biol
; 138: 298-306, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-23856460
10.
Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys.
J Steroid Biochem Mol Biol
; 129(3-5): 115-28, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22249003
11.
C(17,20)-lyase inhibitors. Part 2: design, synthesis and structure-activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C(17,20)-lyase inhibitors.
Bioorg Med Chem
; 12(16): 4313-36, 2004 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15265485
12.
C17,20-lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors.
Bioorg Med Chem
; 12(9): 2251-73, 2004 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15080924
13.
Total synthesis of (-)-bafilomycin A(1).
J Am Chem Soc
; 124(24): 6981-90, 2002 Jun 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-12059221
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