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1.
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Proc Natl Acad Sci U S A
; 111(35): 12853-8, 2014 Sep 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-25136132
2.
SAH derived potent and selective EZH2 inhibitors.
Bioorg Med Chem Lett
; 25(7): 1532-7, 2015 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25746813
3.
SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance.
Mol Cancer Ther
; 21(1): 3-15, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34737197
4.
Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling.
Cell Rep
; 30(6): 1935-1950.e8, 2020 02 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32049022
5.
Preclinical characterization of PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
Antimicrob Agents Chemother
; 53(6): 2544-52, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19307358
6.
Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase.
J Med Chem
; 62(17): 7669-7683, 2019 09 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31415173
7.
Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.
PLoS One
; 13(6): e0198374, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29879184
8.
Allosteric inhibitors of hepatitis C polymerase: discovery of potent and orally bioavailable carbon-linked dihydropyrones.
J Med Chem
; 50(17): 3969-72, 2007 Aug 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-17658778
9.
SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/ß-Catenin and Hippo/YAP Signaling.
Dev Cell
; 37(1): 47-57, 2016 Apr 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-27046831
10.
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
J Med Chem
; 59(18): 8306-25, 2016 Sep 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27512831
11.
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.
J Med Chem
; 54(9): 3368-85, 2011 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-21438541
12.
Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
J Med Chem
; 59(24): 11196, 2016 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27936698
13.
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
J Med Chem
; 52(5): 1255-8, 2009 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-19209845
14.
Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors.
Bioorg Med Chem Lett
; 16(18): 4834-8, 2006 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16824756
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