Detalles de la búsqueda
1.
A novel system to determine activity of individual uridine 5'-diphospho-glucuronosyltransferase (UGT) isoforms: Recombinant UGT-beads.
J Biol Chem
; 300(5): 107278, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38599380
2.
Mechanistic Static Model based Prediction of Transporter Substrate Drug-Drug Interactions Utilizing Atorvastatin and Rifampicin.
Pharm Res
; 40(12): 3025-3042, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37821766
3.
Characterization of Divergent Metabolic Pathways in Elucidating an Unexpected, Slow-Forming, and Long Half-Life Major Metabolite of Iclepertin.
Pharm Res
; 40(8): 1901-1913, 2023 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-37280472
4.
Mode of action and human relevance assessment of male CD-1 mouse renal adenocarcinoma associated with lifetime exposure to empagliflozin.
J Appl Toxicol
; 42(10): 1570-1584, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35393688
5.
Advances in the study of drug metabolism - symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX).
Drug Metab Rev
; 52(3): 395-407, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32456484
6.
Evaluation of Erythromycin as a Tool to Assess CYP3A Contribution of Low Clearance Compounds in a Long-Term Hepatocyte Culture.
Drug Metab Dispos
; 48(8): 690-697, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32503882
7.
Human Liver Microsomes Immobilized on Magnetizable Beads: A Novel Approach to Study In Vitro Drug Metabolism.
Drug Metab Dispos
; 48(8): 645-654, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32474441
8.
Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions.
Pharm Res
; 37(12): 250, 2020 Nov 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33237382
9.
Prediction and Quantification of Hepatic Transporter-Mediated Uptake of Pitavastatin Utilizing a Combination of the Relative Activity Factor Approach and Mechanistic Modeling.
Drug Metab Dispos
; 46(7): 953-963, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29666154
10.
N-Methylation of BI 187004 by Thiol S-Methyltransferase.
Drug Metab Dispos
; 46(6): 770-778, 2018 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-29514826
11.
Optimization of a drug transporter probe cocktail: potential screening tool for transporter-mediated drug-drug interactions.
Br J Clin Pharmacol
; 84(9): 1941-1949, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29665130
12.
Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design.
Drug Metab Dispos
; 43(4): 490-509, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25587128
13.
Sex-, Species-, and Tissue-Specific Metabolism of Empagliflozin in Male Mouse Kidney Forms an Unstable Hemiacetal Metabolite (M466/2) That Degrades to 4-Hydroxycrotonaldehyde, a Reactive and Cytotoxic Species.
Chem Res Toxicol
; 28(1): 103-15, 2015 Jan 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-25489797
14.
Mechanisms underlying benign and reversible unconjugated hyperbilirubinemia observed with faldaprevir administration in hepatitis C virus patients.
J Pharmacol Exp Ther
; 351(2): 403-12, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25204339
15.
Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac.
Drug Metab Dispos
; 42(3): 394-406, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24366904
16.
Enzyme-transporter interplay in the formation and clearance of abundant metabolites of faldaprevir found in excreta but not in circulation.
Drug Metab Dispos
; 42(3): 384-93, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24346834
17.
Comparison of Commonly Used and New Methods to Determine Small Molecule Non-Specific Binding to Human Liver Microsomes.
J Pharm Sci
; 113(7): 1987-1995, 2024 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-38615815
18.
Variability in P-glycoprotein inhibitory potency (IC50) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria.
Drug Metab Dispos
; 41(7): 1347-66, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23620485
19.
Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions.
Drug Metab Dispos
; 41(7): 1367-74, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23620486
20.
The deaminated metabolite of gemcitabine, 2',2'-difluorodeoxyuridine, modulates the rate of gemcitabine transport and intracellular phosphorylation via deoxycytidine kinase.
Drug Metab Dispos
; 39(11): 2013-6, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21832002