Detalles de la búsqueda
1.
Tailored horseshoe-shaped nicotinonitrile scaffold as dual promising c-Met and Pim-1 inhibitors: Design, synthesis, SAR and in silico study.
Bioorg Chem
; 143: 106988, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-37995644
2.
Rationale design of novel substituted 1,3,5-triazine candidates as dual IDH1(R132H)/ IDH2(R140Q) inhibitors with high selectivity against acute myeloid leukemia: In vitro and in vivo preclinical investigations.
Bioorg Chem
; 149: 107483, 2024 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-38805913
3.
Development of new thieno[2,3-d]pyrimidines as dual EGFR and STAT3 inhibitors endowed with anticancer and pro-apoptotic activities.
Bioorg Chem
; 143: 107101, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38183682
4.
An overview of recent advancements in small molecules suppression of oncogenic signaling of K-RAS: an updated review.
Mol Divers
; 2024 Jan 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-38289431
5.
Identification of 3-(5-cyano-6-oxo-pyridin-2-yl)benzenesulfonamides as novel anticancer agents endowed with EGFR inhibitory activity.
Arch Pharm (Weinheim)
; 357(1): e2300449, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-37828544
6.
Novel 4-(2-arylidenehydrazineyl)thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico insights.
Bioorg Chem
; 140: 106799, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37625210
7.
Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R).
J Enzyme Inhib Med Chem
; 38(1): 2241674, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37548154
8.
Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies.
J Enzyme Inhib Med Chem
; 38(1): 2171029, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36701269
9.
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors.
J Enzyme Inhib Med Chem
; 38(1): 2203389, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37122176
10.
Papaverinol-N-Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening.
Molecules
; 28(4)2023 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36838572
11.
Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition.
Bioorg Chem
; 129: 106126, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36108589
12.
Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity.
J Enzyme Inhib Med Chem
; 37(1): 1043-1052, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35437108
13.
Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents.
J Enzyme Inhib Med Chem
; 37(1): 2765-2785, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36210545
14.
Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies.
J Enzyme Inhib Med Chem
; 37(1): 2489-2511, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36093880
15.
Design, synthesis, and molecular docking study of new monastrol analogues as kinesin spindle protein inhibitors.
Arch Pharm (Weinheim)
; 353(8): e2000060, 2020 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-32452567
16.
Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors.
Bioorg Med Chem
; 27(23): 115126, 2019 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31648875
17.
Corrigendum to "Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors" [Bioorg. Med. Chem. 27 (2019) 115126].
Bioorg Med Chem
; 28(19): 115687, 2020 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32826133
18.
Corrigendum to "Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors" [Bioorg. Med. Chem. 27 (2019) 115126].
Bioorg Med Chem
; 28(2): 115255, 2020 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31862309
19.
Drosophila melanogaster as a model organism for diabetes II treatment by the ethyl acetate fraction of Atriplex halimus L.
J Exp Zool A Ecol Integr Physiol
; 341(6): 702-716, 2024 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-38623920
20.
A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments.
Eur J Med Chem
; 274: 116527, 2024 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38810335