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1.
Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model.
Drug Metab Dispos
; 44(6): 821-32, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-27026679
2.
Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma.
Pharm Res
; 33(5): 1204-19, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26869174
3.
α-Aryl pyrrolidine sulfonamides as TRPA1 antagonists.
Bioorg Med Chem Lett
; 26(2): 495-498, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26706172
4.
Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors.
Bioorg Med Chem Lett
; 26(15): 3518-24, 2016 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27346791
5.
Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility.
Bioorg Med Chem Lett
; 25(3): 529-41, 2015 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25556090
6.
Mechanistic studies of the cationic binding pocket of CYP2C9 in vitro and in silico: metabolism of nonionizable analogs of tienilic acid.
Drug Metab Dispos
; 42(11): 1955-63, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25187484
7.
Drug-drug interaction potential of marketed oncology drugs: in vitro assessment of time-dependent cytochrome P450 inhibition, reactive metabolite formation and drug-drug interaction prediction.
Pharm Res
; 29(7): 1960-76, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22415140
8.
A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation.
Mol Pharmacol
; 77(2): 218-27, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19884280
9.
Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions.
Drug Metab Lett
; 12(1): 3-13, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29237391
10.
Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development.
J Med Chem
; 61(6): 2227-2245, 2018 03 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-29457982
11.
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.
J Med Chem
; 61(8): 3641-3659, 2018 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29590749
12.
Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.
J Med Chem
; 60(10): 4458-4473, 2017 05 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-28445037
13.
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
ACS Med Chem Lett
; 8(1): 84-89, 2017 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28105280
14.
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J Med Chem
; 59(6): 2760-79, 2016 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26919761
15.
Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System.
ACS Med Chem Lett
; 6(8): 925-9, 2015 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-26288695
16.
Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349.
ACS Med Chem Lett
; 4(1): 103-7, 2013 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900569
17.
Evaluation of time-dependent cytochrome p450 inhibition in a high-throughput, automated assay: introducing a novel area under the curve shift approach.
Drug Metab Lett
; 6(1): 43-53, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22372554
18.
Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases.
Biochem Pharmacol
; 83(1): 149-63, 2012 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22020119
19.
Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.
J Med Chem
; 55(12): 5887-900, 2012 Jun 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-22626259
20.
Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy.
Biochem Pharmacol
; 75(8): 1677-87, 2008 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18342837
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