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1.
Enhanced selectivity profile of pyrazole-urea based DFG-out p38alpha inhibitors.
Bioorg Med Chem Lett
; 20(16): 4885-91, 2010 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20620059
2.
Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?
Bioorg Med Chem Lett
; 19(1): 226-9, 2009 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19019675
3.
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
Nat Struct Mol Biol
; 11(12): 1192-7, 2004 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-15543157
4.
Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor.
Mol Cancer Ther
; 7(7): 1880-9, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18606718
5.
2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase).
Bioorg Med Chem Lett
; 18(23): 6171-4, 2008 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18951019
6.
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.
Bioorg Med Chem Lett
; 18(24): 6501-4, 2008 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18952427
7.
4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.
J Med Chem
; 50(21): 5090-102, 2007 Oct 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-17880056
8.
Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family.
J Med Chem
; 59(17): 8103-24, 2016 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27491023
9.
The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay.
Chem Biol Drug Des
; 74(6): 547-59, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19843080
10.
Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms.
Arthritis Rheum
; 56(10): 3347-57, 2007 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-17907188
11.
N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-D-aspartate receptor antagonists for the treatment of pain.
Bioorg Med Chem Lett
; 17(16): 4599-603, 2007 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17562362
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