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1.
Challenging the anticolorectal cancer capacity of quinoxaline-based scaffold via triazole ligation unveiled new efficient dual VEGFR-2/MAO-B inhibitors.
Bioorg Chem
; 143: 107102, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38211551
2.
The first-in-class pyrazole-based dual InhA-VEGFR inhibitors towards integrated antitubercular host-directed therapy.
Bioorg Chem
; 145: 107179, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38367430
3.
Chemosensitization of non-small cell lung cancer to sorafenib via non-hydroxamate s-triazinedione-based MMP-9/10 inhibitors.
Bioorg Chem
; 144: 107155, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38306827
4.
Discovery of novel benzimidazole acyclic C-nucleoside DNA intercalators halting breast cancer growth.
Arch Pharm (Weinheim)
; 357(1): e2300454, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-37867206
5.
Superior anti-pulmonary viral potential of Natrialba sp. M6-producing surfactin and C50 carotenoid pigment with unveiling its action modes.
Virol J
; 20(1): 249, 2023 10 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-37904234
6.
Engineered Microencapsulated Lactoferrin Nanoconjugates for Oral Targeted Treatment of Colon Cancer.
Biomacromolecules
; 24(5): 2149-2163, 2023 05 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37039769
7.
Battling colorectal cancer via s-triazine-based MMP-10/13 inhibitors armed with electrophilic warheads for concomitant ferroptosis induction; the first-in-class dual-acting agents.
Bioorg Chem
; 141: 106839, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37703744
8.
New spiro-indeno[1,2-b]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for halting non-small cell lung cancer; stereoselective synthesis, molecular dynamics and structural insights.
J Enzyme Inhib Med Chem
; 38(1): 2281260, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37994663
9.
Targeting the interplay between MMP-2, CA II and VEGFR-2 via new sulfonamide-tethered isomeric triazole hybrids; Microwave-assisted synthesis, computational studies and evaluation.
Bioorg Chem
; 124: 105816, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35489270
10.
Anticancer activity of novel 3-(furan-2-yl)pyrazolyl and 3-(thiophen-2-yl)pyrazolyl hybrid chalcones: Synthesis and in vitro studies.
Arch Pharm (Weinheim)
; 355(3): e2100381, 2022 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-34939695
11.
Design, Synthesis, Pharmacodynamic and In Silico Pharmacokinetic Evaluation of Some Novel Biginelli-Derived Pyrimidines and Fused Pyrimidines as Calcium Channel Blockers.
Molecules
; 27(7)2022 Mar 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35408650
12.
Enhancing the Anticancer Potential of Targeting Tumor-Associated Metalloenzymes via VEGFR Inhibition by New Triazolo[4,3-a]pyrimidinone Acyclo C-Nucleosides Multitarget Agents.
Molecules
; 27(8)2022 Apr 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35458618
13.
Transforming Type II to Type I c-Met kinase inhibitors via combined scaffold hopping and structure-guided synthesis of new series of 1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4-one derivatives.
Bioorg Chem
; 116: 105304, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34534756
14.
Structural optimization, synthesis and in vitro synergistic anticancer activities of combinations of new N3-substituted dihydropyrimidine calcium channel blockers with cisplatin and etoposide.
Bioorg Chem
; 115: 105262, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34411980
15.
Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators.
Bioorg Chem
; 117: 105427, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34794098
16.
Halting Tumor Progression via Novel Non-Hydroxamate Triazole-Based Mannich Bases MMP-2/9 Inhibitors; Design, Microwave-Assisted Synthesis, and Biological Evaluation.
Int J Mol Sci
; 22(19)2021 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-34638665
17.
Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology.
Bioorg Chem
; 96: 103616, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32032847
18.
Chlorinated tacrine analogs: Design, synthesis and biological evaluation of their anti-cholinesterase activity as potential treatment for Alzheimer's disease.
Bioorg Chem
; 86: 557-568, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30782574
19.
Dual VEGFR-2/PIM-1 kinase inhibition towards surmounting the resistance to antiangiogenic agents via hybrid pyridine and thienopyridine-based scaffolds: Design, synthesis and biological evaluation.
Bioorg Chem
; 92: 103189, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31473473
20.
Synthesis of some new C2 substituted dihydropyrimidines and their electrophysiological evaluation as L-/T-type calcium channel blockers.
Bioorg Chem
; 88: 102915, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31005784