Detalles de la búsqueda
1.
An inhibitor-like binding mode of a carbonic anhydrase activator within the active site of isoform II.
Bioorg Med Chem Lett
; 21(9): 2764-8, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21036610
2.
Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.
Bioorg Med Chem Lett
; 21(11): 3216-21, 2011 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21549597
3.
Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II-trithiocarbonate adduct--an inhibitor mimicking the sulfonamide and urea binding to the enzyme.
Bioorg Med Chem Lett
; 20(2): 474-8, 2010 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20005709
4.
Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.
J Am Chem Soc
; 131(8): 3057-62, 2009 Mar 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-19206230
5.
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.
Bioorg Med Chem Lett
; 19(5): 1371-5, 2009 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19186056
6.
Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma.
Bioorg Med Chem Lett
; 19(23): 6565-70, 2009 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19854054
7.
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.
Bioorg Med Chem
; 17(3): 1214-21, 2009 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19119014
8.
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.
Bioorg Med Chem Lett
; 18(8): 2567-73, 2008 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18374572
9.
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.
Bioorg Med Chem Lett
; 18(15): 4282-6, 2008 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18640037
10.
Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorg Med Chem Lett
; 18(1): 152-8, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18024029
11.
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
Bioorg Med Chem Lett
; 18(3): 999-1005, 2008 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18162396
12.
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.
Bioorg Med Chem
; 16(18): 8373-8, 2008 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18774300
13.
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.
Bioorg Med Chem
; 16(7): 3933-40, 2008 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18242998
14.
Reconstitution of carbonic anhydrase activity of the cell-surface-binding protein of vaccinia virus.
Biochem J
; 407(1): 61-7, 2007 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17614791
15.
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme.
Chem Commun (Camb)
; (2): 156-8, 2007 Jan 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-17180231
16.
Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.
J Med Chem
; 49(10): 3019-27, 2006 May 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-16686544
17.
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.
J Med Chem
; 49(24): 7024-31, 2006 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-17125255
18.
The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes.
Nucleic Acids Res
; 31(5): 1464-9, 2003 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12595554
19.
Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain.
J Med Chem
; 59(4): 1648-53, 2016 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-26731131
20.
Simple and rapid physico-chemical methods to examine action of antimalarial drugs with hemin: its application to Artemisia annua constituents.
Life Sci
; 70(7): 769-78, 2002 Jan 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-11833740