Detalles de la búsqueda
1.
Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs.
Mol Pharm
; 16(10): 4292-4301, 2019 10 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31503493
2.
Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs.
Mol Pharm
; 14(10): 3248-3257, 2017 10 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28763226
3.
Application of Pd-Catalyzed Cross-Coupling Reactions in the Synthesis of 5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles that Inhibit ALK5 Kinase.
J Org Chem
; 81(23): 11841-11856, 2016 12 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27934472
4.
1,3-Dipolar Cycloaddition in the Preparation of New Fused Heterocyclic Compounds via Thermal Initiation.
Molecules
; 21(2)2016 Feb 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-26861268
5.
A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis.
Sci Transl Med
; 15(708): eabn7491, 2023 08 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37556558
6.
Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold.
Eur J Med Chem
; 259: 115674, 2023 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37536209
7.
The combination of immunotherapy and a glutamine metabolism inhibitor represents an effective therapeutic strategy for advanced and metastatic murine pancreatic adenocarcinoma.
Int Immunopharmacol
; 118: 110150, 2023 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-37030115
8.
Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-l-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery.
J Med Chem
; 66(22): 15493-15510, 2023 11 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-37949450
9.
Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice.
Pharmaceutics
; 15(9)2023 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-37765332
10.
Discovery of Orally Bioavailable and Brain-Penetrable Prodrugs of the Potent nSMase2 Inhibitor DPTIP.
J Med Chem
; 65(16): 11111-11125, 2022 08 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35930706
11.
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
Sci Adv
; 8(46): eabq5925, 2022 11 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-36383674
12.
Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement.
Curr Drug Metab
; 22(9): 735-745, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34488583
13.
Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA).
SLAS Discov
; 25(9): 1026-1037, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32452709
14.
The Novel Glutamine Antagonist Prodrug JHU395 Has Antitumor Activity in Malignant Peripheral Nerve Sheath Tumor.
Mol Cancer Ther
; 19(2): 397-408, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31594823
15.
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells.
J Clin Invest
; 130(7): 3865-3884, 2020 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32324593
16.
Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs.
J Med Chem
; 62(7): 3524-3538, 2019 04 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30892035
17.
JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.
Neuropsychopharmacology
; 44(4): 683-694, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30127344
18.
Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.
Neuropsychopharmacology
; 44(6): 1178, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30862949
19.
N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs.
J Med Chem
; 61(9): 3918-3929, 2018 05 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29648826
20.
ALK5 kinase inhibitory activity and synthesis of 2,3,4-substituted 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles.
Eur J Med Chem
; 127: 632-642, 2017 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28135685