Detalles de la búsqueda
1.
Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors.
Bioorg Med Chem
; 24(23): 6149-6165, 2016 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27825552
2.
Design and synthesis of piperazine derivatives as a novel class of γ-secretase modulators that selectively lower Aß42 production.
Bioorg Med Chem
; 23(9): 1923-34, 2015 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25842363
3.
Design, synthesis, and biological activities of 1-aryl-1,4-diazepan-2-one derivatives as novel triple reuptake inhibitors.
Bioorg Med Chem Lett
; 24(16): 3898-902, 2014 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25017029
4.
Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1â³ binding site.
Bioorg Med Chem
; 22(19): 5487-505, 2014 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25192810
5.
Novel triple reuptake inhibitors with low risk of CAD associated liabilities: design, synthesis and biological activities of 4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine and related compounds.
Bioorg Med Chem
; 21(15): 4600-13, 2013 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23769168
6.
[Introduction of industry precompetitive consortium to promote microbiome based drug discovery in Japan].
Nihon Yakurigaku Zasshi
; 158(4): 326-331, 2023.
Artículo
en Japonés
| MEDLINE | ID: mdl-37394554
7.
Characterization and Demonstration of Mock Communities as Control Reagents for Accurate Human Microbiome Community Measurements.
Microbiol Spectr
; 10(2): e0191521, 2022 04 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-35234490
8.
A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.
J Neurosci
; 30(33): 11157-66, 2010 Aug 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-20720123
9.
Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists.
Bioorg Med Chem
; 19(18): 5539-52, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21856163
10.
Validation and standardization of DNA extraction and library construction methods for metagenomics-based human fecal microbiome measurements.
Microbiome
; 9(1): 95, 2021 04 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-33910647
11.
Complete Genome Sequence of Flavonifractor plautii JCM 32125T.
Microbiol Resour Announc
; 9(17)2020 Apr 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-32327522
12.
Complete Genome Sequence of Blautia producta JCM 1471T.
Microbiol Resour Announc
; 9(17)2020 Apr 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-32327523
13.
Complete Genome Sequence of Collinsella aerofaciens JCM 10188T.
Microbiol Resour Announc
; 9(16)2020 Apr 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32299873
14.
Complete Genome Sequence of Megamonas funiformis JCM 14723T.
Microbiol Resour Announc
; 9(16)2020 Apr 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32299874
15.
Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach.
J Med Chem
; 60(2): 608-626, 2017 01 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-27966948
16.
T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist.
Eur J Pharmacol
; 438(3): 129-35, 2002 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-11909603
17.
Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach.
J Med Chem
; 57(21): 8886-902, 2014 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25264600
18.
Ameliorative effects of a non-competitive BACE1 inhibitor TAK-070 on Aß peptide levels and impaired learning behavior in aged rats.
Brain Res
; 1361: 146-56, 2010 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-20849831
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