Detalles de la búsqueda
1.
Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy.
Bioorg Med Chem Lett
; 24(9): 2177-81, 2014 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24685546
2.
Tigecycline displays in vivo bactericidal activity against extended-spectrum-ß-lactamase-producing Enterobacteriaceae after 72-hour exposure period.
Antimicrob Agents Chemother
; 57(1): 640-2, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23114764
3.
In vitro activity of novel gyrase inhibitors against a highly resistant population of Pseudomonas aeruginosa.
Antimicrob Agents Chemother
; 57(6): 2887-9, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23571537
4.
Comparative in vivo efficacies of epithelial lining fluid exposures of tedizolid, linezolid, and vancomycin for methicillin-resistant Staphylococcus aureus in a mouse pneumonia model.
Antimicrob Agents Chemother
; 56(5): 2342-6, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22354302
5.
In vivo comparison of CXA-101 (FR264205) with and without tazobactam versus piperacillin-tazobactam using human simulated exposures against phenotypically diverse gram-negative organisms.
Antimicrob Agents Chemother
; 56(1): 544-9, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22064538
6.
Bronchopulmonary disposition of micafungin in healthy adult volunteers.
Antimicrob Agents Chemother
; 53(3): 1218-20, 2009 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19114675
7.
Identifying exposure targets for treatment of staphylococcal pneumonia with ceftobiprole.
Antimicrob Agents Chemother
; 53(8): 3294-301, 2009 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-19451287
8.
Pharmacodynamic characterization of ceftobiprole in experimental pneumonia caused by phenotypically diverse Staphylococcus aureus strains.
Antimicrob Agents Chemother
; 52(7): 2389-94, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18411322
9.
Comparative in vivo efficacy of meropenem, imipenem, and cefepime against Pseudomonas aeruginosa expressing MexA-MexB-OprM efflux pumps.
Diagn Microbiol Infect Dis
; 57(2): 153-61, 2007 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-16930925
10.
Bactericidal efficacy of ABI-0043, a novel rifamycin, in a murine pneumococcal pneumonia model.
J Antibiot (Tokyo)
; 59(12): 804-7, 2006 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-17323649
11.
Evaluation of telithromycin against Streptococcus pneumoniae with ribosomal mutations utilizing in vitro time-kill methodology.
Int J Antimicrob Agents
; 26(4): 331-4, 2005 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-16144757
12.
Assessment of the efficacy of telithromycin simulating human exposures against S. pneumoniae with ribosomal mutations in a murine pneumonia model.
Int J Antimicrob Agents
; 25(6): 530-4, 2005 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15894464
13.
Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.
ACS Med Chem Lett
; 6(7): 822-6, 2015 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-26191374
14.
Efficacy of clarithromycin against Streptococcus pneumoniae expressing mef(A)-mediated resistance.
Int J Antimicrob Agents
; 23(5): 498-501, 2004 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15120730
15.
Physical compatibility of telavancin hydrochloride with select i.v. drugs during simulated Y-site administration.
Am J Health Syst Pharm
; 68(23): 2265-70, 2011 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22095816
16.
Interscience Conference on Antimicrobial Agents and Chemotherapy--42nd meeting. Investigational drugs. 27-30 September 2002, San Diego, CA, USA.
IDrugs
; 5(11): 1033-5, 2002 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-14649641
17.
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships.
J Med Chem
; 51(17): 5243-63, 2008 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-18690678
18.
Pharmacodynamic profile of telithromycin against macrolide- and fluoroquinolone-resistant Streptococcus pneumoniae in a neutropenic mouse thigh model.
Antimicrob Agents Chemother
; 49(1): 188-94, 2005 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-15616295
19.
Pharmacodynamics of moxifloxacin and levofloxacin at simulated epithelial lining fluid drug concentrations against Streptococcus pneumoniae.
Antimicrob Agents Chemother
; 48(4): 1215-21, 2004 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15047522
20.
Pharmacodynamic profile of daptomycin against Enterococcus species and methicillin-resistant Staphylococcus aureus in a murine thigh infection model.
J Antimicrob Chemother
; 52(3): 405-11, 2003 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-12917254