Detalles de la búsqueda
1.
Physiologically based pharmacokinetic models of small molecules and therapeutic antibodies: a mini-review on fundamental concepts and applications.
Biopharm Drug Dispos
; 37(2): 75-92, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26461173
2.
New challenges and opportunities in nonclinical safety testing of biologics.
Regul Toxicol Pharmacol
; 69(2): 226-33, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24755365
3.
Confounding parameters in preclinical assessment of blood-brain barrier permeation: an overview with emphasis on species differences and effect of disease states.
Mol Pharm
; 10(5): 1581-95, 2013 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-23256608
4.
Anti-neuropilin-1 (MNRP1685A): unexpected pharmacokinetic differences across species, from preclinical models to humans.
Pharm Res
; 29(9): 2512-21, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22707361
5.
Population pharmacokinetic and pharmacodynamic modeling of MNRP1685A in cynomolgus monkeys using two-target quasi-steady-state (QSS) model.
J Pharmacokinet Pharmacodyn
; 39(2): 217-26, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22382554
6.
Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.
Bioconjug Chem
; 22(10): 1994-2004, 2011 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-21913715
7.
A hybrid approach to advancing quantitative prediction of tissue distribution of basic drugs in human.
Toxicol Appl Pharmacol
; 250(2): 194-212, 2011 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21034759
8.
Potential errors in the volume of distribution estimation of therapeutic proteins composed of differently cleared components.
J Pharmacokinet Pharmacodyn
; 38(5): 581-93, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21779940
9.
Effects of charge on antibody tissue distribution and pharmacokinetics.
Bioconjug Chem
; 21(12): 2153-63, 2010 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21053952
10.
Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the Hedgehog pathway inhibitor GDC-0449 in dogs: an investigation using preclinical studies and physiologically based pharmacokinetic modeling.
Drug Metab Dispos
; 38(7): 1029-38, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20406853
11.
Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys.
Drug Metab Dispos
; 38(4): 600-5, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20071453
12.
Development and evaluation of a novel method for preclinical measurement of tissue vascular volume.
Mol Pharm
; 7(5): 1848-57, 2010 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-20704296
13.
Whole body physiologically-based pharmacokinetic models: their use in clinical drug development.
Expert Opin Drug Metab Toxicol
; 4(9): 1143-52, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18721109
14.
Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins.
J Immunol Res
; 2016: 2342187, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27579329
15.
New antibacterial agents derived from the DNA gyrase inhibitor cyclothialidine.
J Med Chem
; 47(6): 1487-513, 2004 Mar 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-14998336
16.
Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes.
Biochem Pharmacol
; 64(11): 1637-50, 2002 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12429353
17.
Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection.
Toxicol Lett
; 138(1-2): 29-49, 2003 Feb 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-12559691
18.
Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition.
J Pharm Sci
; 91(5): 1358-70, 2002 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-11977112
19.
Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.
J Pharm Sci
; 91(1): 129-56, 2002 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-11782904
20.
Physiologically based pharmacokinetic (PBPK) modeling of disposition of epiroprim in humans.
J Pharm Sci
; 92(10): 1990-2007, 2003 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-14502539