Detalles de la búsqueda
1.
Structural and Kinetic Characterization of a Novel N-acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652.
Drug Metab Dispos
; 43(7): 936-43, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25887455
2.
Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors.
Bioorg Med Chem Lett
; 19(5): 1488-91, 2009 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19179073
3.
Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.
Bioorg Med Chem Lett
; 19(5): 1492-5, 2009 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19181525
4.
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
J Med Chem
; 47(24): 5825-8, 2004 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-15537338
5.
Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics.
J Med Chem
; 46(25): 5294-7, 2003 Dec 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-14640538
6.
Quantitation of small molecules using high-resolution accurate mass spectrometers - a different approach for analysis of biological samples.
Rapid Commun Mass Spectrom
; 23(7): 1085-94, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19263405
7.
Metabolite identification of small interfering RNA duplex by high-resolution accurate mass spectrometry.
Rapid Commun Mass Spectrom
; 22(12): 1871-81, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18470869
8.
High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a 'first-line' approach for metabolite identification studies.
Rapid Commun Mass Spectrom
; 22(7): 1053-61, 2008 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-18327855
9.
Fractional mass filtering as a means to assess circulating metabolites in early human clinical studies.
Rapid Commun Mass Spectrom
; 22(22): 3510-6, 2008 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-18853407
10.
Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides.
Bioorg Med Chem Lett
; 16(23): 5968-72, 2006 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16987662
11.
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.
J Pharmacol Exp Ther
; 313(1): 199-206, 2005 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15608073
12.
Implications of matrix effects in ultra-fast gradient or fast isocratic liquid chromatography with mass spectrometry in drug discovery.
Rapid Commun Mass Spectrom
; 16(2): 92-8, 2002.
Artículo
en Inglés
| MEDLINE | ID: mdl-11754253
13.
Liquid chromatography/tandem mass spectrometric quantification with metabolite screening as a strategy to enhance the early drug discovery process.
Rapid Commun Mass Spectrom
; 16(12): 1225-31, 2002.
Artículo
en Inglés
| MEDLINE | ID: mdl-12112275
14.
Fast LC/MS in the analysis of small molecules.
Anal Bioanal Chem
; 377(5): 788-802, 2003 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-12904948
15.
Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides.
ChemMedChem
; 1(8): 807-11, 2006 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16902933
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