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1.
Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation.
J Biol Chem
; 294(23): 9029-9036, 2019 06 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31018963
2.
Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F.
N Engl J Med
; 374(1): 54-61, 2016 Jan 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26698910
3.
The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase.
J Biol Chem
; 292(38): 15705-15716, 2017 09 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28724631
4.
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations.
Proc Natl Acad Sci U S A
; 112(11): 3493-8, 2015 Mar 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-25733882
5.
Acquired resistance to crizotinib from a mutation in CD74-ROS1.
N Engl J Med
; 368(25): 2395-401, 2013 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-23724914
6.
Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
J Med Chem
; 66(7): 4888-4909, 2023 04 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36940470
7.
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).
J Med Chem
; 64(1): 644-661, 2021 01 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33356246
8.
Identification of small-molecule inhibitors of the JIP-JNK interaction.
Biochem J
; 420(2): 283-94, 2009 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-19243309
9.
Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
ACS Med Chem Lett
; 11(6): 1175-1184, 2020 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32550998
10.
Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors.
Biochemistry
; 48(23): 5339-49, 2009 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-19459657
11.
Synthesis and SAR of 4-substituted-2-aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.
Bioorg Med Chem Lett
; 19(8): 2099-102, 2009 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19327989
12.
Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase.
ACS Med Chem Lett
; 9(9): 872-877, 2018 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30258533
13.
Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer.
Cancer Discov
; 8(6): 714-729, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29650534
14.
Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility.
PLoS One
; 10(9): e0138616, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26398286
15.
PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models.
Cancer Cell
; 28(1): 70-81, 2015 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-26144315
16.
Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design.
Protein Sci
; 23(10): 1332-40, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25043846
17.
Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors.
Biosci Rep
; 34(2)2014 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27919031
18.
Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations.
J Med Chem
; 57(11): 4720-44, 2014 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24819116
19.
Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.
J Med Chem
; 57(4): 1170-87, 2014 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24432909
20.
Sensitivity of selected human tumor models to PF-04217903, a novel selective c-Met kinase inhibitor.
Mol Cancer Ther
; 11(4): 1036-47, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22389468