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1.
Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.
Bioorg Med Chem Lett
; 19(17): 5209-13, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19631533
2.
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
Bioorg Med Chem Lett
; 19(15): 4092-6, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19539468
3.
Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).
J Med Chem
; 53(6): 2656-60, 2010 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-20196613
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