Detalles de la búsqueda
1.
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas.
Acta Pharmacol Sin
; 2024 Jun 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38834683
2.
18F-Labeled oaminopyridyl alkynyl radioligands targeting colony-stimulating factor 1 receptor for neuroinflammation imaging.
Bioorg Med Chem
; 83: 117233, 2023 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36933438
3.
Design and synthesis of 1H-pyrazolo[3,4-d]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors.
Bioorg Chem
; 140: 106811, 2023 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37659145
4.
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo.
Cancer Sci
; 113(2): 709-720, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-34855271
5.
Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance.
Mol Cancer
; 19(1): 90, 2020 05 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32404161
6.
Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation.
Bioorg Med Chem Lett
; 30(16): 127327, 2020 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32631532
7.
Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors.
Acta Pharmacol Sin
; 41(3): 415-422, 2020 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-31316181
8.
Discovery and Biological evaluation of pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors.
Bioorg Med Chem
; 27(15): 3390-3395, 2019 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31221612
9.
C11, a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis.
Acta Pharmacol Sin
; 40(6): 823-832, 2019 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-30487650
10.
Correction: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance.
Mol Cancer
; 22(1): 139, 2023 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-37598189
11.
Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R.
Acta Pharmacol Sin
; 39(11): 1768-1776, 2018 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-29968849
12.
C-H Trifluoromethylation of 2-Substituted/Unsubstituted Aminonaphthoquinones at Room Temperature with Bench-Stable (CF3SO2)2Zn: Synthesis and Antiproliferative Evaluation.
J Org Chem
; 82(13): 6795-6800, 2017 07 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28589724
13.
Correction to: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance.
Mol Cancer
; 20(1): 102, 2021 Aug 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34404402
14.
Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors.
Bioorg Med Chem
; 24(12): 2673-80, 2016 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27131639
15.
DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo.
Acta Pharmacol Sin
; 37(3): 398-407, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26806300
16.
2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFR(L858R/T79°M).
Bioorg Med Chem Lett
; 25(19): 4277-81, 2015 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26259806
17.
DCLAK11, a multi-tyrosine kinase inhibitor, exhibits potent antitumor and antiangiogenic activity in vitro.
Acta Pharmacol Sin
; 36(10): 1266-76, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26027659
18.
DW09849, a selective phosphatidylinositol 3-kinase (PI3K) inhibitor, prevents PI3K signaling and preferentially inhibits proliferation of cells containing the oncogenic mutation p110α (H1047R).
J Pharmacol Exp Ther
; 348(3): 432-41, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24361696
19.
Suzuki coupling based synthesis and in vitro cytotoxic evaluation of 7-heteroaryl-substituted camptothecin analogs.
Bioorg Med Chem Lett
; 24(6): 1597-9, 2014 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24529870
20.
Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors.
Bioorg Med Chem
; 22(7): 2366-78, 2014 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24565969