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1.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from?

Toogood, Peter L; Clauw, Daniel J; Phadke, Sameer; Hoffman, David.

Pharmacol Res ; 165: 105465, 2021 03.

Artículo en Inglés | MEDLINE | ID: mdl-33529750

2.

Small molecule immuno-oncology therapeutic agents.

Toogood, Peter L.

Bioorg Med Chem Lett ; 28(3): 319-329, 2018 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-29326017

3.

Sterol metabolism controls T(H)17 differentiation by generating endogenous RORÎ³ agonists.

Hu, Xiao; Wang, Yahong; Hao, Ling-Yang; Liu, Xikui; Lesch, Chuck A; Sanchez, Brian M; Wendling, Jay M; Morgan, Rodney W; Aicher, Tom D; Carter, Laura L; Toogood, Peter L; Glick, Gary D.

Nat Chem Biol ; 11(2): 141-7, 2015 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-25558972

4.

Corrigendum: Sterol metabolism controls TH17 differentiation by generating endogenous RORÎ³ agonists.

Hu, Xiao; Wang, Yahong; Hao, Ling-Yang; Liu, Xikui; Lesch, Chuck A; Sanchez, Brian M; Wendling, Jay M; Morgan, Rodney W; Aicher, Tom D; Carter, Laura L; Toogood, Peter L; Glick, Gary D.

Nat Chem Biol ; 11(9): 741, 2015 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-26284677

5.

Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-Î³ (RORÎ³) Agonist for Use in Treating Cancer.

Aicher, Thomas D; Van Huis, Chad A; Hurd, Alexander R; Skalitzky, Donald J; Taylor, Clarke B; Beleh, Omar M; Glick, Gary; Toogood, Peter L; Yang, Bing; Zheng, Tao; Huo, Changxin; Gao, Jie; Qiao, Chenxi; Tian, Xiaolong; Zhang, Junping; Demock, Kellie; Hao, Ling-Yang; Lesch, Charles A; Morgan, Rodney W; Moisan, Jacques; Wang, Yahong; Scatina, JoAnn; Paulos, Chrystal M; Zou, Weiping; Carter, Laura L; Hu, Xiao.

J Med Chem ; 64(18): 13410-13428, 2021 09 23.

Artículo en Inglés | MEDLINE | ID: mdl-34499493

6.

COVID-19: Living through Another Pandemic.

Osman, Essam Eldin A; Toogood, Peter L; Neamati, Nouri.

ACS Infect Dis ; 6(7): 1548-1552, 2020 07 10.

Artículo en Inglés | MEDLINE | ID: mdl-32388976

7.

Synthesis of (-)-PNU-286607 by asymmetric cyclization of alkylidene barbiturates.

Ruble, J Craig; Hurd, Alexander R; Johnson, Timothy A; Sherry, Debra A; Barbachyn, Michael R; Toogood, Peter L; Bundy, Gordon L; Graber, David R; Kamilar, Gregg M.

J Am Chem Soc ; 131(11): 3991-7, 2009 Mar 25.

Artículo en Inglés | MEDLINE | ID: mdl-19260642

8.

Mitochondrial drugs.

Toogood, Peter L.

Curr Opin Chem Biol ; 12(4): 457-63, 2008 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-18602018

9.

Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase.

Montgomery, Justin I; Toogood, Peter L; Hutchings, Kim M; Liu, Jia; Narasimhan, Lakshmi; Braden, Timothy; Dermyer, Michael R; Kulynych, Angela D; Smith, Yvonne D; Warmus, Joseph S; Taylor, Clarke.

Bioorg Med Chem Lett ; 19(3): 665-9, 2009 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-19121937

10.

The synthesis of azadirachtin: a potent insect antifeedant.

Ley, Steven V; Abad-Somovilla, Antonio; Anderson, James C; Ayats, Carles; Bänteli, Rolf; Beckmann, Edith; Boyer, Alistair; Brasca, Maria G; Brice, Abigail; Broughton, Howard B; Burke, Brenda J; Cleator, Ed; Craig, Donald; Denholm, Alastair A; Denton, Ross M; Durand-Reville, Thomas; Gobbi, Luca B; Göbel, Michael; Gray, Brian Lawrence; Grossmann, Robert B; Gutteridge, Claire E; Hahn, Norbert; Harding, Sarah L; Jennens, David C; Jennens, Lynn; Lovell, Peter J; Lovell, Helen J; de la Puente, Mary L; Kolb, Hartmuth C; Koot, Win-Jan; Maslen, Sarah L; McCusker, Catherine F; Mattes, Amos; Pape, Andrew R; Pinto, Andrea; Santafianos, Dinos; Scott, James S; Smith, Stephen C; Somers, Andrew Q; Spilling, Christopher D; Stelzer, Frank; Toogood, Peter L; Turner, Richard M; Veitch, Gemma E; Wood, Anthony; Zumbrunn, Cornelia.

Chemistry ; 14(34): 10683-704, 2008.

Artículo en Inglés | MEDLINE | ID: mdl-18821532

11.

A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6.

Baughn, Linda B; Di Liberto, Maurizio; Wu, Kaida; Toogood, Peter L; Louie, Tracey; Gottschalk, Rachel; Niesvizky, Ruben; Cho, Hearn; Ely, Scott; Moore, Malcolm A S; Chen-Kiang, Selina.

Cancer Res ; 66(15): 7661-7, 2006 Aug 01.

Artículo en Inglés | MEDLINE | ID: mdl-16885367

12.

The kinome is not enough.

Toogood, Peter L.

Chem Biol ; 12(10): 1057-8, 2005 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-16242646

13.

Synthetic RORÎ³ agonists regulate multiple pathways to enhance antitumor immunity.

Hu, Xiao; Liu, Xikui; Moisan, Jacques; Wang, Yahong; Lesch, Charles A; Spooner, Chauncey; Morgan, Rodney W; Zawidzka, Elizabeth M; Mertz, David; Bousley, Dick; Majchrzak, Kinga; Kryczek, Ilona; Taylor, Clarke; Van Huis, Chad; Skalitzky, Don; Hurd, Alexander; Aicher, Thomas D; Toogood, Peter L; Glick, Gary D; Paulos, Chrystal M; Zou, Weiping; Carter, Laura L.

Oncoimmunology ; 5(12): e1254854, 2016.

Artículo en Inglés | MEDLINE | ID: mdl-28123897

14.

Progress toward the development of agents to modulate the cell cycle.

Toogood, Peter L.

Curr Opin Chem Biol ; 6(4): 472-8, 2002 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-12133723

15.

Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4.

VanderWel, Scott N; Harvey, Patricia J; McNamara, Dennis J; Repine, Joseph T; Keller, Paul R; Quin, John; Booth, R John; Elliott, William L; Dobrusin, Ellen M; Fry, David W; Toogood, Peter L.

J Med Chem ; 48(7): 2371-87, 2005 Apr 07.

Artículo en Inglés | MEDLINE | ID: mdl-15801830

16.

Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6.

Toogood, Peter L; Harvey, Patricia J; Repine, Joseph T; Sheehan, Derek J; VanderWel, Scott N; Zhou, Hairong; Keller, Paul R; McNamara, Dennis J; Sherry, Debra; Zhu, Tong; Brodfuehrer, Joanne; Choi, Chung; Barvian, Mark R; Fry, David W.

J Med Chem ; 48(7): 2388-406, 2005 Apr 07.

Artículo en Inglés | MEDLINE | ID: mdl-15801831

17.

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

Fry, David W; Harvey, Patricia J; Keller, Paul R; Elliott, William L; Meade, Maryanne; Trachet, Erin; Albassam, Mudher; Zheng, XianXian; Leopold, Wilbur R; Pryer, Nancy K; Toogood, Peter L.

Mol Cancer Ther ; 3(11): 1427-38, 2004 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-15542782

18.

A short and efficient synthesis of L-5,5,5,5',5',5'-hexafluoroleucine from N-Cbz-L-serine.

Anderson, James T; Toogood, Peter L; Marsh, E Neil G.

Org Lett ; 4(24): 4281-3, 2002 Nov 28.

Artículo en Inglés | MEDLINE | ID: mdl-12443078

19.

Synthesis of an Enantiomerically Pure Serine-Derived Thiazole.

Sowinski, Jennifer A.; Toogood, Peter L..

J Org Chem ; 61(22): 7671-7676, 1996 Nov 01.

Artículo en Inglés | MEDLINE | ID: mdl-11667720

20.

Total Synthesis of Motuporin and 5-[L-Ala]-Motuporin.

Samy, Raghu; Kim, Hong Yong; Brady, Matthew; Toogood, Peter L..

J Org Chem ; 64(8): 2711-2728, 1999 Apr 16.

Artículo en Inglés | MEDLINE | ID: mdl-11674341

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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from?

Small molecule immuno-oncology therapeutic agents.

Sterol metabolism controls T(H)17 differentiation by generating endogenous RORÎ³ agonists.

Corrigendum: Sterol metabolism controls TH17 differentiation by generating endogenous RORÎ³ agonists.

Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-Î³ (RORÎ³) Agonist for Use in Treating Cancer.

COVID-19: Living through Another Pandemic.

Synthesis of (-)-PNU-286607 by asymmetric cyclization of alkylidene barbiturates.

Mitochondrial drugs.

Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase.

The synthesis of azadirachtin: a potent insect antifeedant.

A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6.

The kinome is not enough.

Synthetic RORÎ³ agonists regulate multiple pathways to enhance antitumor immunity.

Progress toward the development of agents to modulate the cell cycle.

Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4.

Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6.

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

A short and efficient synthesis of L-5,5,5,5',5',5'-hexafluoroleucine from N-Cbz-L-serine.

Synthesis of an Enantiomerically Pure Serine-Derived Thiazole.

Total Synthesis of Motuporin and 5-[L-Ala]-Motuporin.