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1.
Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J Biol Chem
; 290(33): 20044-59, 2015 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-26085101
2.
Identification of LY3522348: A Highly Selective and Orally Efficacious Ketohexokinase Inhibitor.
J Med Chem
; 66(23): 15960-15976, 2023 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37992274
3.
Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Sci Rep
; 8(1): 15458, 2018 10 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-30337562
4.
A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose.
J Med Chem
; 60(13): 5933-5939, 2017 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28613895
5.
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
J Med Chem
; 60(23): 9599-9616, 2017 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29072452
6.
Use of Osmotic Pumps to Establish the Pharmacokinetic-Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors.
J Med Chem
; 59(12): 5810-22, 2016 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-27194201
7.
Identification of antimicrobial compounds active against intracellular Staphylococcus aureus.
FEMS Immunol Med Microbiol
; 45(2): 245-52, 2005 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15963705
8.
A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.
Med Chem
; 1(1): 13-9, 2005 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-16789881
9.
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
J Med Chem
; 57(24): 10476-85, 2014 Dec 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25415648
10.
Sequence selective recognition of DNA by hairpin conjugates of a racemic seco-cyclopropaneindoline-2-benzofurancarboxamide and polyamides.
Bioorg Med Chem Lett
; 12(16): 2245-8, 2002 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-12127548
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