Detalles de la búsqueda
1.
Accraspiroketides A-B, Phenylnaphthacenoid-Derived Polyketides with Unprecedented [6 + 6+6 + 6] + [5 + 5] Spiro-Architecture.
J Nat Prod
; 87(4): 831-836, 2024 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-38551509
2.
Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitors.
J Enzyme Inhib Med Chem
; 38(1): 2218602, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37254958
3.
Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFRT790M/BRAFV600E Pathways.
Molecules
; 28(3)2023 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36770936
4.
Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities.
Bioorg Chem
; 120: 105616, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35078049
5.
Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects.
Bioorg Chem
; 116: 105302, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34464816
6.
Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity.
Bioorg Chem
; 112: 104960, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34020242
7.
Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease.
Bioorg Chem
; 116: 105363, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34555629
8.
Discovery and Biosynthetic Investigation of a New Antibacterial Dehydrated Non-Ribosomal Tripeptide.
Angew Chem Int Ed Engl
; 60(6): 3229-3237, 2021 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33107670
9.
Productive Syntheses of Privileged Scaffolds Inspired by the Recognition of a Diels-Alder Pattern Common to Three Classes of Natural Products.
Chemistry
; 26(67): 15477-15481, 2020 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32428343
10.
Characterization of the promiscuous N-acyl CoA transferase, LgoC, in legonoxamine biosynthesis.
Org Biomol Chem
; 18(12): 2219-2222, 2020 03 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-32159577
11.
Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors.
Bioorg Chem
; 104: 104260, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32920363
12.
Structure-Based Design, Synthesis and Bioactivity of a New Anti-TNFα Cyclopeptide.
Molecules
; 25(4)2020 Feb 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-32093030
13.
Enzymatic Reconstitution and Biosynthetic Investigation of the Bacterial Carbazole Neocarazostatin A.
J Org Chem
; 84(24): 16323-16328, 2019 12 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-31729221
14.
Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators.
Bioorg Med Chem Lett
; 26(18): 4403-4407, 2016 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27542310
15.
A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway.
Angew Chem Int Ed Engl
; 55(11): 3596-9, 2016 Mar 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26846478
16.
Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins.
Angew Chem Int Ed Engl
; 54(43): 12697-701, 2015 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-26206556
17.
In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569.
Behav Pharmacol
; 25(2): 182-5, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24603340
18.
Isolation and synthesis of pulmonarins A and B, acetylcholinesterase inhibitors from the colonial ascidian Synoicum pulmonaria.
J Nat Prod
; 77(2): 364-9, 2014 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-24547899
19.
Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents.
Pharmaceuticals (Basel)
; 16(7)2023 Jul 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-37513950
20.
Discovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action.
RSC Med Chem
; 14(4): 734-744, 2023 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-37122549