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1.
Assessment of the Utility of Physiologically-based Pharmacokinetic Model for prediction of Pharmacokinetics in Chinese and Japanese Populations.
Int J Med Sci
; 18(16): 3718-3727, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34790045
2.
Enzalutamide and Apalutamide: In Vitro Chemical Reactivity Studies and Activity in a Mouse Drug Allergy Model.
Chem Res Toxicol
; 33(1): 211-222, 2020 01 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31538772
3.
Metabolism of a 5HT6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction.
Drug Metab Dispos
; 46(7): 934-942, 2018 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-29695615
4.
A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance.
Drug Metab Dispos
; 46(6): 865-878, 2018 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-29487142
5.
Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective.
Drug Metab Dispos
; 44(8): 1399-423, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27052879
6.
Drug metabolism and drug interactions: potential application to antituberculosis drugs.
J Infect Dis
; 211 Suppl 3: S107-14, 2015 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26009614
7.
Contribution of metabolites to P450 inhibition-based drug-drug interactions: scholarship from the drug metabolism leadership group of the innovation and quality consortium metabolite group.
Drug Metab Dispos
; 43(4): 620-30, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25655830
8.
Disposition and metabolic profiling of [(14)C]cerlapirdine using accelerator mass spectrometry.
Drug Metab Dispos
; 42(12): 2023-32, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25217486
9.
Physiologically Based Pharmacokinetic Modeling of the Drug-Drug Interaction Between CYP3A4 Substrate Glasdegib and Moderate CYP3A4 Inducers in Lieu of a Clinical Study.
J Clin Pharmacol
; 64(1): 80-93, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-37731282
10.
Integrating Clinical Variability into PBPK Models for Virtual Bioequivalence of Single and Multiple Doses of Tofacitinib Modified-Release Dosage Form.
Clin Pharmacol Ther
; 2024 May 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-38797995
11.
Drug metabolites as cytochrome p450 inhibitors: a retrospective analysis and proposed algorithm for evaluation of the pharmacokinetic interaction potential of metabolites in drug discovery and development.
Drug Metab Dispos
; 41(12): 2047-55, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23792812
12.
Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates.
Nat Microbiol
; 7(10): 1536-1546, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36065062
13.
The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?
J Pharmacol Exp Ther
; 338(1): 345-52, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21508084
14.
Physiologically-Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co-Administration with the UGT Inhibitor Mefenamic Acid.
CPT Pharmacometrics Syst Pharmacol
; 10(2): 127-136, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33314761
15.
Liver Toxicity Observed With Lorlatinib When Combined With Strong CYP3A Inducers: Evaluation of Cynomolgus Monkey as a Nonclinical Model for Assessing the Mechanism of Combinational Toxicity.
Toxicol Sci
; 182(2): 183-194, 2021 08 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34021354
16.
Physiologically-Based Pharmacokinetic Modeling in Renal and Hepatic Impairment Populations: A Pharmaceutical Industry Perspective.
Clin Pharmacol Ther
; 110(2): 297-310, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33270249
17.
Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure and Support Dosing Recommendations for Potential Drug-Drug Interactions or in Special Populations: An Example Using Tofacitinib.
J Clin Pharmacol
; 60(12): 1617-1628, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32592424
18.
Ex vivo (human skin) and in vivo (minipig) permeation of propylene glycol applied as topical crisaborole ointment, 2.
Int J Pharm
; 576: 118847, 2020 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31759994
19.
Physiologically Based Pharmacokinetic Modeling Suggests Limited Drug-Drug Interaction for Fesoterodine When Coadministered With Mirabegron.
J Clin Pharmacol
; 59(11): 1505-1518, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31090092
20.
Steady-state pharmacokinetics of conjugated equine estrogens in healthy, postmenopausal women.
J Reprod Med
; 53(2): 97-101, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18357800