Detalles de la búsqueda
1.
Identification of AHCY inhibitors using novel high-throughput mass spectrometry.
Biochem Biophys Res Commun
; 491(1): 1-7, 2017 09 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28533090
2.
Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors.
Bioorg Med Chem Lett
; 27(5): 1311-1315, 2017 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28169164
3.
2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase.
Bioorg Med Chem
; 25(14): 3658-3670, 2017 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28533114
4.
Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders.
Chem Pharm Bull (Tokyo)
; 65(11): 1058-1077, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-29093293
5.
Discovery of TAK-960: an orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Bioorg Med Chem Lett
; 23(12): 3662-6, 2013 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23664874
6.
A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(Sâ)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease.
J Neurochem
; 119(6): 1330-40, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21992552
7.
Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization.
J Med Chem
; 64(2): 1103-1115, 2021 01 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-33404239
8.
Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment.
J Exp Med
; 195(5): 547-58, 2002 Mar 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-11877478
9.
New phenotypic cytotoxicity assay for ROS-inducing compounds using rat renal epithelial cells.
Toxicol Lett
; 331: 227-234, 2020 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32522578
10.
New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase.
ACS Med Chem Lett
; 11(8): 1645-1652, 2020 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34345355
11.
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
J Med Chem
; 63(6): 3215-3226, 2020 03 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32142284
12.
Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent.
J Med Chem
; 63(3): 1084-1104, 2020 02 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31895562
13.
Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.
Bioorg Med Chem
; 17(5): 2017-29, 2009 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19200745
14.
Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist.
J Med Chem
; 62(3): 1167-1179, 2019 02 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30652849
15.
Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor.
Sci Adv
; 5(5): eaav3660, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31131319
16.
Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors.
J Med Chem
; 61(17): 7710-7728, 2018 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30067358
17.
Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a.
Eur J Pharmacol
; 812: 138-146, 2017 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28705714
18.
Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders.
J Med Chem
; 60(18): 7677-7702, 2017 09 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28796496
19.
CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.
Nat Commun
; 8(1): 7, 2017 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28232751
20.
Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives.
J Med Chem
; 56(16): 6478-94, 2013 Aug 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-23906342