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1.
A Study of the Effect of Cyclosporine on Fevipiprant Pharmacokinetics and its Absolute Bioavailability Using an Intravenous Microdose Approach.
Drug Metab Dispos
; 48(10): 917-924, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32739890
2.
Verification of a physiologically based pharmacokinetic model of ritonavir to estimate drug-drug interaction potential of CYP3A4 substrates.
Biopharm Drug Dispos
; 39(3): 152-163, 2018 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-29451681
3.
Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors.
Xenobiotica
; 46(10): 862-7, 2016 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26887925
4.
Novel in vitro-in vivo extrapolation (IVIVE) method to predict hepatic organ clearance in rat.
Pharm Res
; 29(2): 603-17, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22011931
5.
Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug-drug interactions.
Biopharm Drug Dispos
; 33(4): 179-94, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22407504
6.
Characterization of human organic cation transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-mediated transport of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel small molecule survivin suppressant.
Drug Metab Dispos
; 38(1): 1-4, 2010 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19833842
7.
Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations.
Clin Pharmacol Ther
; 107(5): 1082-1115, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31628859
8.
Relationship between exposure of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a "funny" if current channel inhibitor, and heart rate reduction in tachycardia-induced beagle dogs.
Drug Metab Dispos
; 37(7): 1427-33, 2009 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-19359407
9.
Identification of human metabolites of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a novel If channel inhibitor, and investigation of the transporter-mediated renal and hepatic excretion of these metabolites.
Drug Metab Dispos
; 37(8): 1646-57, 2009 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-19439489
10.
Investigation of long-term retention of unchanged (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide, a novel "funny" If current channel inhibitor, and its metabolites in the eyeball and thoracic aorta of rats.
Drug Metab Dispos
; 37(11): 2137-44, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19704029
11.
Examining P-gp efflux kinetics guided by the BDDCS - Rational selection of in vitro assay designs and mathematical models.
Eur J Pharm Sci
; 132: 132-141, 2019 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-30857914
12.
Hepatic uptake and excretion of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a novel if channel inhibitor, in rats and humans.
Drug Metab Dispos
; 36(6): 1030-8, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18332079
13.
Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) - a comparison with the chemical inhibition method.
Drug Metab Pers Ther
; 32(4): 191-200, 2017 Dec 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-29176011
14.
New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data.
Eur J Pharm Sci
; 86: 96-102, 2016 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-26948853
15.
Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction.
Drug Metab Pers Ther
; 31(4): 221-228, 2016 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27718490
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