Detalles de la búsqueda
1.
Modeling Pharmacokinetic Natural Product-Drug Interactions for Decision-Making: A NaPDI Center Recommended Approach.
Pharmacol Rev
; 73(2): 847-859, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33712517
2.
Maternal and Fetal Exposure to (-)-Δ9-tetrahydrocannabinol and Its Major Metabolites in Pregnant Mice Is Differentially Impacted by P-glycoprotein and Breast Cancer Resistance Protein.
Drug Metab Dispos
; 51(3): 269-275, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36446608
3.
Interpretation of Protein-Mediated Uptake of Statins by Hepatocytes Is Confounded by the Residual Statin-Protein Complex.
Drug Metab Dispos
; 51(10): 1381-1390, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37429727
4.
A Physiologically-Based Pharmacokinetic Model for Cannabidiol in Healthy Adults, Hepatically-Impaired Adults, and Children.
Drug Metab Dispos
; 51(6): 743-752, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36972999
5.
Predicting Regional Respiratory Tissue and Systemic Concentrations of Orally Inhaled Drugs through a Novel PBPK Model.
Drug Metab Dispos
; 50(5): 519-528, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35246463
6.
Estimation of Fetal-to-Maternal Unbound Steady-State Plasma Concentration Ratio of P-Glycoprotein and/or Breast Cancer Resistance Protein Substrate Drugs Using a Maternal-Fetal Physiologically Based Pharmacokinetic Model.
Drug Metab Dispos
; 50(5): 613-623, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35149540
7.
Comprehensive Predictions of Cytochrome P450 (P450)-Mediated In Vivo Cannabinoid-Drug Interactions Based on Reversible and Time-Dependent P450 Inhibition in Human Liver Microsomes.
Drug Metab Dispos
; 50(4): 351-360, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35115300
8.
Is the Protein-Mediated Uptake of Drugs by Organic Anion Transporting Polypeptides a Real Phenomenon or an Artifact?
Drug Metab Dispos
; 50(9): 1132-1141, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35351775
9.
Characterizing and Quantifying Extrahepatic Metabolism of (-)-Δ9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, (±)-11-Hydroxy-Δ9-THC (11-OH-THC).
Drug Metab Dispos
; 50(6): 734-740, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35370140
10.
Applications, Challenges, and Outlook for PBPK Modeling and Simulation: A Regulatory, Industrial and Academic Perspective.
Pharm Res
; 39(8): 1701-1731, 2022 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-35552967
11.
Prediction of Pregnancy-Induced Changes in Secretory and Total Renal Clearance of Drugs Transported by Organic Anion Transporters.
Drug Metab Dispos
; 49(10): 929-937, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34315779
12.
Successful Prediction of Human Fetal Exposure to P-Glycoprotein Substrate Drugs Using the Proteomics-Informed Relative Expression Factor Approach and PBPK Modeling and Simulation.
Drug Metab Dispos
; 49(10): 919-928, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34426410
13.
Tetrahydrocannabinol and Its Major Metabolites Are Not (or Are Poor) Substrates or Inhibitors of Human P-Glycoprotein [ATP-Binding Cassette (ABC) B1] and Breast Cancer Resistance Protein (ABCG2).
Drug Metab Dispos
; 49(10): 910-918, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34326138
14.
Development and Verification of a Linked Δ 9-THC/11-OH-THC Physiologically Based Pharmacokinetic Model in Healthy, Nonpregnant Population and Extrapolation to Pregnant Women.
Drug Metab Dispos
; 49(7): 509-520, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33952608
15.
Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach.
Drug Metab Dispos
; 49(2): 159-168, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33051248
16.
Abundance of P-glycoprotein and Breast Cancer Resistance Protein Measured by Targeted Proteomics in Human Epileptogenic Brain Tissue.
Mol Pharm
; 18(6): 2263-2273, 2021 06 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34008992
17.
Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450.
Drug Metab Dispos
; 48(10): 1008-1017, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32587099
18.
Successful Prediction of Positron Emission Tomography-Imaged Metformin Hepatic Uptake Clearance in Humans Using the Quantitative Proteomics-Informed Relative Expression Factor Approach.
Drug Metab Dispos
; 48(11): 1210-1216, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32843330
19.
Gestational Age-Dependent Abundance of Human Placental Transporters as Determined by Quantitative Targeted Proteomics.
Drug Metab Dispos
; 48(9): 735-741, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32591415
20.
In Vivo-to-In Vitro Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach.
Drug Metab Dispos
; 49(6): 470-478, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33824168