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1.
Regulatory Experience Assessing the Carcinogenic Potential of a Monoclonal Antibody Inhibiting PCSK9, Bococizumab, Including a 2-Year Carcinogenicity Study in Rats.
Int J Toxicol
; 41(5): 389-401, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35672934
2.
Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™.
Int J Toxicol
; 41(4): 276-290, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35603517
3.
Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Intravenous Infusions of PF-07304814 (Lufotrelvir) in Participants Hospitalized With COVID-19.
Open Forum Infect Dis
; 10(8): ofad355, 2023 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-37559753
4.
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Nat Commun
; 12(1): 6055, 2021 10 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34663813
5.
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19.
bioRxiv
; 2021 Feb 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32935104
6.
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Science
; 374(6575): 1586-1593, 2021 Dec 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34726479
7.
BALB/c mice orally pretreated with diclofenac have augmented and accelerated PLNA responses to diclofenac.
Toxicology
; 172(3): 217-30, 2002 Apr 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-11893420
8.
Diclofenac activates T cells in the direct popliteal lymph node assay and selectively induces IgG(1) and IgE against co-injected TNP-OVA.
Toxicol Lett
; 131(3): 167-80, 2002 May 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-11992736
9.
Investigating the TNP-OVA and direct popliteal lymph node assays for the detection of immunostimulation by drugs associated with anaphylaxis in humans.
J Appl Toxicol
; 22(3): 177-83, 2002.
Artículo
en Inglés
| MEDLINE | ID: mdl-12015798
10.
Oxazolone and diclofenac-induced popliteal lymph node assay reactions are attenuated in mice orally pretreated with the respective compound: potential role for the induction of regulatory mechanisms following enteric administration.
Toxicol Appl Pharmacol
; 189(2): 120-33, 2003 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12781630
11.
Task force report: future research needs for the prevention and management of immune-mediated drug hypersensitivity reactions.
J Allergy Clin Immunol
; 109(3): S461-78, 2002 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-11897992
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