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1.
Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology.
Neurobiol Dis
; 161: 105548, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34752923
2.
Pharmacological Characterization of the Novel and Selective α7 Nicotinic Acetylcholine Receptor-Positive Allosteric Modulator BNC375.
J Pharmacol Exp Ther
; 373(2): 311-324, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32094294
3.
MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy.
J Pharmacol Exp Ther
; 374(2): 252-263, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32493725
4.
Discovery of 4-arylquinoline-2-carboxamides, highly potent and selective class of mGluR2 negative allosteric modulators: From HTS to activity in animal models.
Bioorg Med Chem Lett
; 30(9): 127066, 2020 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32173198
5.
Preclinical to Human Translational Pharmacology of the Novel M1 Positive Allosteric Modulator MK-7622.
J Pharmacol Exp Ther
; 365(3): 556-566, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29563325
6.
Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species.
Bioorg Med Chem Lett
; 28(6): 1122-1126, 2018 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29534798
7.
fMRI study of the role of glutamate NMDA receptor in the olfactory adaptation in rats: Insights into cellular and molecular mechanisms of olfactory adaptation.
Neuroimage
; 149: 348-360, 2017 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28163142
8.
The dual orexin receptor antagonist, DORA-22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine.
J Neurochem
; 142(2): 204-214, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28444767
9.
fMRI study of olfaction in the olfactory bulb and high olfactory structures of rats: Insight into their roles in habituation.
Neuroimage
; 127: 445-455, 2016 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26522425
10.
Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis.
Bioorg Med Chem Lett
; 26(4): 1260-4, 2016 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26810316
11.
The M1 Muscarinic Positive Allosteric Modulator PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys.
J Pharmacol Exp Ther
; 355(3): 442-50, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26446308
12.
Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders.
J Pharmacol Exp Ther
; 350(3): 495-505, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24947466
13.
Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators.
BMC Neurosci
; 15: 109, 2014 Sep 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-25242351
14.
Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia.
J Med Chem
; 66(2): 1157-1171, 2023 01 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-36624931
15.
Discovery of [11C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators.
ACS Med Chem Lett
; 14(7): 986-992, 2023 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37465306
16.
Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator.
ACS Med Chem Lett
; 14(8): 1088-1094, 2023 Aug 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37583812
17.
A Novel Biomarker of Neuronal Glutamate Metabolism in Nonhuman Primates Using Localized 1H-Magnetic Resonance Spectroscopy: Development and Effects of BNC375, an α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator.
Biol Psychiatry Cogn Neurosci Neuroimaging
; 7(6): 598-606, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33309567
18.
The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 attenuates a scopolamine-induced deficit in a novel rodent attention task.
J Neurogenet
; 25(4): 120-6, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22070409
19.
Effects of a novel M4 muscarinic positive allosteric modulator on behavior and cognitive deficits relevant to Alzheimer's disease and schizophrenia in rhesus monkey.
Neuropharmacology
; 197: 108754, 2021 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34389398
20.
3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts.
Bioorg Med Chem Lett
; 20(10): 3129-33, 2010 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20409708