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1.
Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency.
J Immunol
; 190(7): 3732-9, 2013 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23455501
2.
Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.
J Neurosci
; 32(25): 8532-44, 2012 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-22723693
3.
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule.
Bioorg Med Chem Lett
; 23(6): 1860-4, 2013 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23416001
4.
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule.
Bioorg Med Chem Lett
; 23(2): 412-6, 2013 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23237839
5.
Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.
Bioorg Med Chem Lett
; 23(1): 346-50, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23177787
6.
Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists.
Bioorg Med Chem Lett
; 22(22): 6923-8, 2012 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23062550
7.
Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012.
Bioorg Med Chem Lett
; 22(2): 1044-8, 2012 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22197142
8.
Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor.
Bioorg Med Chem Lett
; 22(15): 5084-8, 2012 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22738637
9.
Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012.
Bioorg Med Chem Lett
; 22(15): 5035-40, 2012 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22749871
10.
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor.
Bioorg Med Chem Lett
; 22(10): 3467-72, 2012 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22507963
11.
Respiratory syncytial virus induces host RNA stress granules to facilitate viral replication.
J Virol
; 84(23): 12274-84, 2010 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-20844027
12.
Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2.
Proc Natl Acad Sci U S A
; 105(29): 10209-14, 2008 Jul 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-18621683
13.
Venezuelan equine encephalitis virus replicon particles encoding respiratory syncytial virus surface glycoproteins induce protective mucosal responses in mice and cotton rats.
J Virol
; 81(24): 13710-22, 2007 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-17928349
14.
Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4).
J Biomol Screen
; 20(7): 858-68, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-25877150
15.
Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe.
ChemMedChem
; 9(8): 1677-82, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24692176
16.
Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7.
ACS Chem Neurosci
; 5(12): 1221-37, 2014 Dec 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-25225882
17.
Respiratory syncytial virus assembles into structured filamentous virion particles independently of host cytoskeleton and related proteins.
PLoS One
; 7(7): e40826, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22808269
18.
Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode.
ACS Chem Neurosci
; 3(12): 1025-36, 2012 Dec 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-23259038
19.
Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.
ACS Chem Neurosci
; 3(11): 884-95, 2012 Nov 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-23173069
20.
Human metapneumovirus nucleoprotein and phosphoprotein interact and provide the minimal requirements for inclusion body formation.
J Gen Virol
; 89(Pt 11): 2698-2708, 2008 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-18931065