Detalles de la búsqueda
1.
Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling.
Xenobiotica
; 51(3): 316-323, 2021 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-33179995
2.
Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice.
Chem Res Toxicol
; 33(2): 634-639, 2020 02 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-31854189
3.
Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19.
Xenobiotica
; 48(7): 720-726, 2018 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-28686070
4.
Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models.
Xenobiotica
; 48(10): 1072-1077, 2018 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-29034770
5.
R-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys.
Xenobiotica
; 48(2): 206-210, 2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-28136132
6.
Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies.
Biopharm Drug Dispos
; 39(2): 116-121, 2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29136681
7.
Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models.
Biopharm Drug Dispos
; 38(7): 439-442, 2017 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28608515
8.
Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers.
Drug Metab Dispos
; 44(7): 911-5, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27098744
9.
Caffeine 7-N-demethylation and C-8-oxidation mediated by liver microsomal cytochrome P450 enzymes in common marmosets.
Xenobiotica
; 46(7): 573-578, 2016 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-26503341
10.
Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol and midazolam, in common marmosets (Callithrix jacchus).
Xenobiotica
; 46(2): 163-8, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26114209
11.
Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling.
Xenobiotica
; 46(12): 1049-1055, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26916082
12.
Pre-incubation with cyclosporine A potentiates its inhibitory effects on pitavastatin uptake mediated by recombinantly expressed cynomolgus monkey hepatic organic anion transporting polypeptide.
Biopharm Drug Dispos
; 37(8): 479-490, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27603548
13.
In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9.
Biopharm Drug Dispos
; 37(6): 379-83, 2016 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-27417918
14.
Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole.
Drug Metab Dispos
; 43(10): 1408-16, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26228688
15.
Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.
Xenobiotica
; 45(10): 881-6, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26075833
16.
Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation.
Xenobiotica
; 45(4): 312-21, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25364857
17.
Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450.
Drug Metab Dispos
; 42(5): 867-71, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24553381
18.
Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor.
Chem Res Toxicol
; 27(2): 304-308, 2014 Feb 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-24460184
19.
Pitavastatin as an in vivo probe for studying hepatic organic anion transporting polypeptide-mediated drug-drug interactions in cynomolgus monkeys.
Drug Metab Dispos
; 41(10): 1875-82, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23929936
20.
In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.
Chem Res Toxicol
; 26(3): 486-9, 2013 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-23419139