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1.
Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides.
Bioorg Med Chem
; 25(7): 2260-2265, 2017 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28284867
2.
Optimized Proteomic Mass Spectrometry Characterization of Recombinant Human µ-Opioid Receptor Functionally Expressed in Pichia pastoris Cell Lines.
J Proteome Res
; 14(8): 3162-73, 2015 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26090583
3.
Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptide.
Bioorg Med Chem Lett
; 25(22): 5190-3, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26463133
4.
Synthesis, biological evaluation and structural characterization of novel glycopeptide analogues of nociceptin N/OFQ.
Org Biomol Chem
; 9(17): 6133-42, 2011 Sep 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-21773621
5.
Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aß Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer's Disease Drug Discovery.
J Med Chem
; 63(6): 3205-3214, 2020 03 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-32124607
6.
Iodination of salicylic acid improves its binding to transthyretin.
Biochim Biophys Acta
; 1784(3): 512-7, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-18155178
7.
Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
Bioorg Med Chem Lett
; 19(17): 5270-3, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19651509
8.
Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD.
Sci Rep
; 9(1): 13672, 2019 09 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-31541162
9.
Arylation of Phe and Tyr side chains of unprotected peptides by a Suzuki-Miyaura reaction in water.
Org Lett
; 10(15): 3243-5, 2008 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-18598051
10.
Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design.
Biochem J
; 408(1): 131-8, 2007 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17683281
11.
Insights on the Interaction between Transthyretin and Aß in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal.
J Med Chem
; 60(13): 5749-5758, 2017 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28587455
12.
Benzyl-2-Acetamido-2-Deoxy-α-d-Galactopyranoside Increases Human Immunodeficiency Virus Replication and Viral Outgrowth Efficacy In Vitro.
Front Immunol
; 8: 2010, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-29472913
13.
Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor.
Biochem J
; 388(Pt 2): 615-21, 2005 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15689188
14.
Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative.
Biochem J
; 381(Pt 2): 351-6, 2004 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15080795
15.
Tuning transthyretin amyloidosis inhibition properties of iododiflunisal by combinatorial engineering of the nonsalicylic ring substitutions.
ACS Comb Sci
; 17(1): 32-8, 2015 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25394203
16.
Modulation of the Interaction between a Peptide Ligand and a G Protein-Coupled Receptor by Halogen Atoms.
ACS Med Chem Lett
; 6(8): 872-6, 2015 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-26288687
17.
Transthyretin stabilization by iododiflunisal promotes amyloid-ß peptide clearance, decreases its deposition, and ameliorates cognitive deficits in an Alzheimer's disease mouse model.
J Alzheimers Dis
; 39(2): 357-70, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24169237
18.
Modulation of the fibrillogenesis inhibition properties of two transthyretin ligands by halogenation.
J Med Chem
; 56(22): 9110-21, 2013 Nov 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24147937
19.
Proposed Bioactive Conformations of Opiorphin, an Endogenous Dual APN/NEP Inhibitor.
ACS Med Chem Lett
; 3(1): 20-4, 2012 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900367
20.
Structure-activity relationship study of opiorphin, a human dual ectopeptidase inhibitor with antinociceptive properties.
J Med Chem
; 55(3): 1181-8, 2012 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-22224710