Detalles de la búsqueda
1.
Estimation of Protein-Ligand Unbinding Kinetics Using Non-Equilibrium Targeted Molecular Dynamics Simulations.
J Chem Inf Model
; 59(12): 5135-5147, 2019 12 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31697501
2.
The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1.
Bioorg Med Chem Lett
; 23(12): 3620-6, 2013 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23648182
3.
Predictive models assessing the response to ustekinumab highlight the value of therapeutic drug monitoring in Crohn's disease.
Dig Liver Dis
; 55(3): 366-372, 2023 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-35977875
4.
Collecting New Peak and Intermediate Infliximab Levels to Predict Remission in Inflammatory Bowel Diseases.
Inflamm Bowel Dis
; 28(2): 208-217, 2022 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33783494
5.
New approach to determine the healthy immune variations by combining clustering methods.
Sci Rep
; 11(1): 8917, 2021 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-33903641
6.
Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer.
J Med Chem
; 63(2): 512-528, 2020 01 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31721572
7.
Fast NMR Methods for Measuring in the Direct and/or Competition Mode the Dissociation Constants of Chemical Fragments Interacting with a Receptor.
ChemMedChem
; 14(11): 1115-1127, 2019 06 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30925009
8.
Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations.
J Chem Theory Comput
; 14(7): 3859-3869, 2018 Jul 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29768913
9.
An evaporation-free solid-phase extraction method for rapid and accurate analysis of sumatriptan in human plasma by LC-MS/MS.
J Chromatogr B Analyt Technol Biomed Life Sci
; 856(1-2): 9-14, 2007 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17574939
10.
Reconstructing Demography and Social Behavior During the Neolithic Expansion from Genomic Diversity Across Island Southeast Asia.
Genetics
; 204(4): 1495-1506, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27683274
11.
An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery.
J Biomol Screen
; 21(4): 414-21, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26637553
12.
CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.
MAbs
; 8(5): 867-78, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26984268
13.
Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844).
J Med Chem
; 59(15): 7066-74, 2016 08 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27355974
14.
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents.
Sci Rep
; 5: 7642, 2015 Jan 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-25560837
15.
Data mining crystallization databases: knowledge-based approaches to optimize protein crystal screens.
Proteins
; 51(4): 562-8, 2003 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12784215
16.
A pilot study to evaluate the pharmacokinetics of sibutramine in healthy subjects under fasting and fed conditions.
J Pharm Pharm Sci
; 7(3): 345-9, 2004 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-15576015
17.
SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38+ hematologic malignancies.
Clin Cancer Res
; 20(17): 4574-83, 2014 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24987056
18.
Comparison between elementary flux modes analysis and 13C-metabolic fluxes measured in bacterial and plant cells.
BMC Syst Biol
; 5: 95, 2011 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-21682932
19.
Tricyclic series of heat shock protein 90 (Hsp90) inhibitors part I: discovery of tricyclic imidazo[4,5-c]pyridines as potent inhibitors of the Hsp90 molecular chaperone.
J Med Chem
; 54(20): 7206-19, 2011 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21972823
20.
In vitro disintegration and dissolution and in vivo bioequivalence of two alendronate once-weekly formulations.
Arzneimittelforschung
; 56(2): 84-9, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16572922