Detalles de la búsqueda
1.
Rapid Metabolic Profiling of 1 µL Crude Cerebrospinal Fluid by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Can Differentiate De Novo Parkinson's Disease.
Anal Chem
; 95(50): 18352-18360, 2023 12 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38059473
2.
Comprehensive mapping of neurotransmitter networks by MALDI-MS imaging.
Nat Methods
; 16(10): 1021-1028, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31548706
3.
Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.
Mol Psychiatry
; 26(12): 7732-7745, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34480089
4.
Prediction Models for Brain Distribution of Drugs Based on Biomimetic Chromatographic Data.
Molecules
; 27(12)2022 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35744794
5.
Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy.
Neurobiol Dis
; 137: 104738, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31927144
6.
Cross-validated Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Quantitation Protocol for a Pharmaceutical Drug and Its Drug-Target Effects in the Brain Using Time-of-Flight and Fourier Transform Ion Cyclotron Resonance Analyzers.
Anal Chem
; 92(21): 14676-14684, 2020 11 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33086792
7.
A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability.
Neuroimage
; 172: 808-816, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29329980
8.
Simultaneous imaging of multiple neurotransmitters and neuroactive substances in the brain by desorption electrospray ionization mass spectrometry.
Neuroimage
; 136: 129-38, 2016 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27155126
9.
The impact of physicochemical and molecular properties in drug design: navigation in the "drug-like" chemical space.
Adv Exp Med Biol
; 822: 187-94, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25416989
10.
Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation.
Bioorg Med Chem
; 22(7): 2194-207, 2014 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24630695
11.
Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain.
ACS Chem Neurosci
; 15(7): 1335-1341, 2024 Apr 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-38506562
12.
Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson's disease primate model.
NPJ Parkinsons Dis
; 9(1): 118, 2023 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-37495571
13.
Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia.
NPJ Parkinsons Dis
; 8(1): 41, 2022 Apr 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-35418178
14.
Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems.
ACS Chem Biol
; 17(1): 147-158, 2022 01 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34932310
15.
Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle.
Metabolites
; 12(1)2021 Dec 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-35050142
16.
TAAR1-Dependent and -Independent Actions of Tyramine in Interaction With Glutamate Underlie Central Effects of Monoamine Oxidase Inhibition.
Biol Psychiatry
; 90(1): 16-27, 2021 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33579534
17.
Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep.
J Cereb Blood Flow Metab
; 41(12): 3324-3338, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34293940
18.
Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain.
ACS Chem Neurosci
; 12(10): 1811-1823, 2021 05 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-33939923
19.
Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA-induced dyskinesia.
Sci Adv
; 7(2)2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33523980
20.
Mass spectrometry imaging in drug development.
Anal Chem
; 87(3): 1437-55, 2015 Feb 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-25526173