Detalles de la búsqueda
1.
Administration of oxathridine, a first-in-class histamine-3 receptor partial agonist in healthy male volunteers: Central nervous system depression and pseudo-hallucinations.
Br J Clin Pharmacol
; 90(1): 321-335, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37724688
2.
Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers.
Br J Clin Pharmacol
; 88(6): 2909-2925, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35014069
3.
Acute response to cholinergic challenge predicts long-term response to galantamine treatment in patients with Alzheimer's disease.
Br J Clin Pharmacol
; 88(6): 2814-2829, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34964149
4.
The impact of the global COVID-19 pandemic on the conduct of clinical trials: Return to normalcy by considering the practical impact of a structured ethical analysis.
Br J Clin Pharmacol
; 87(3): 837-844, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32668047
5.
Cholinergic and serotonergic modulation of resting state functional brain connectivity in Alzheimer's disease.
Neuroimage
; 199: 143-152, 2019 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31112788
6.
Central nervous system effects of the histamine-3 receptor antagonist CEP-26401, in comparison with modafinil and donepezil, after a single dose in a cross-over study in healthy volunteers.
Br J Clin Pharmacol
; 85(5): 970-985, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30710391
7.
Human pharmacology of positive GABA-A subtype-selective receptor modulators for the treatment of anxiety.
Acta Pharmacol Sin
; 40(5): 571-582, 2019 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-30518829
8.
Serotonergic and cholinergic modulation of functional brain connectivity: A comparison between young and older adults.
Neuroimage
; 169: 312-322, 2018 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29258890
9.
Reversal of mecamylamine-induced effects in healthy subjects by nicotine receptor agonists: Cognitive and (electro) physiological responses.
Br J Clin Pharmacol
; 84(5): 888-899, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29319910
10.
Predicting CYP3A-mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure.
Br J Clin Pharmacol
; 84(2): 358-368, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29072785
11.
Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation.
Hum Brain Mapp
; 38(1): 308-325, 2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27622387
12.
Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry.
Hum Brain Mapp
; 38(4): 2276-2325, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28145075
13.
The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468.
J Pharmacol Exp Ther
; 362(3): 489-503, 2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28663311
14.
Pharmacodynamic response profiles of anxiolytic and sedative drugs.
Br J Clin Pharmacol
; 83(5): 1028-1038, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27922194
15.
Pharmacological vs. classical approaches in the design of first in man clinical drug trials.
Br J Clin Pharmacol
; 83(12): 2807-2812, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28975652
16.
Pharmacokinetics and pharmacodynamics of a new highly concentrated intranasal midazolam formulation for conscious sedation.
Br J Clin Pharmacol
; 83(4): 721-731, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-27780297
17.
The use of a battery of pain models to detect analgesic properties of compounds: a two-part four-way crossover study.
Br J Clin Pharmacol
; 83(5): 976-990, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27862179
18.
An anti-nicotinic cognitive challenge model using mecamylamine in comparison with the anti-muscarinic cognitive challenge using scopolamine.
Br J Clin Pharmacol
; 83(8): 1676-1687, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28217868
19.
Pharmacokinetic/pharmaco-dynamic modelling and simulation of the effects of different cannabinoid receptor type 1 antagonists on Δ(9)-tetrahydrocannabinol challenge tests.
Br J Clin Pharmacol
; 81(4): 713-23, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26617196
20.
Model-based exposure-response analysis to quantify age related differences in the response to scopolamine in healthy subjects.
Br J Clin Pharmacol
; 82(4): 1011-21, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27273555