Detalles de la búsqueda
1.
Safety, antiviral activity and pharmacokinetics of JNJ-64530440, a novel capsid assembly modulator, as 4 week monotherapy in treatment-naive patients with chronic hepatitis B virus infection.
J Antimicrob Chemother
; 77(4): 1102-1110, 2022 03 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-35040959
2.
Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study.
J Infect Dis
; 219(2): 177-185, 2019 01 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30053042
3.
Pharmacokinetic Interactions between Simeprevir and Ledipasvir in Treatment-Naive Hepatitis C Virus Genotype 1-Infected Patients without Cirrhosis Treated with a Simeprevir-Sofosbuvir-Ledipasvir Regimen.
Antimicrob Agents Chemother
; 61(12)2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28971875
4.
Virology analysis in HCV genotype 1-infected patients treated with the combination of simeprevir and TMC647055/ritonavir, with and without ribavirin, and JNJ-56914845.
Virol J
; 14(1): 101, 2017 05 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-28569206
5.
Efficacy, safety and pharmacokinetics of simeprevir and TMC647055/ritonavir with or without ribavirin and JNJ-56914845 in HCV genotype 1 infection.
BMC Gastroenterol
; 17(1): 26, 2017 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28187751
6.
A single, oral dose of the TLR7 agonist JNJ-64794964 induces transcriptomic and phenotypic changes in peripheral immune cells in healthy adults.
Antivir Ther
; 28(3): 13596535231172878, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37199270
7.
Population pharmacokinetic/pharmacodynamic models of JNJ-64794964, a toll-like receptor 7 agonist, in healthy adult participants.
Antivir Ther
; 28(1): 13596535231151626, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36691849
8.
Rapid HCV-RNA decline with once daily TMC435: a phase I study in healthy volunteers and hepatitis C patients.
Gastroenterology
; 138(3): 913-21, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19852962
9.
Safety, tolerability, pharmacokinetics, and pharmacodynamics of oral JNJ-64794964, a TLR-7 agonist, in healthy adults.
Antivir Ther
; 26(3-5): 58-68, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35485332
10.
Pharmacokinetics, safety and tolerability of single- and multiple-ascending doses of JNJ-64530440, a novel hepatitis B virus capsid assembly modulator, in healthy volunteers.
Antivir Ther
; 26(1-2): 13-24, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-35485346
11.
Pharmacokinetics-pharmacodynamics of a respiratory syncytial virus fusion inhibitor in the cotton rat model.
Antimicrob Agents Chemother
; 54(11): 4534-9, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20823290
12.
Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. 2. Discovery of a morpholinopropylaminobenzimidazole derivative (TMC353121).
J Med Chem
; 51(4): 875-96, 2008 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-18254606
13.
Powder for reconstitution of the anti-HIV-1 drug TMC278 - Formulation development, stability and animal studies.
Eur J Pharm Biopharm
; 70(3): 853-60, 2008 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-18657611
14.
Dog model with implanted pump to test boosters for antiretroviral medication.
Int J Pharm
; 355(1-2): 45-52, 2008 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18082980
15.
Development of an implantable infusion pump for sustained anti-HIV drug administration.
Int J Pharm
; 355(1-2): 38-44, 2008 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18337029
16.
Phase I study on safety and pharmacokinetics of a novel influenza endonuclease inhibitor, AL-794 (JNJ-64155806), following single- and multiple-ascending doses in healthy adults.
Antivir Ther
; 23(7): 555-566, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29927386
17.
Characterization of the interaction of 2-hydroxypropyl-beta-cyclodextrin with itraconazole at pH 2, 4, and 7.
J Pharm Sci
; 91(6): 1414-22, 2002 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-12115841
18.
Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
J Med Chem
; 57(5): 1880-92, 2014 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24144360
19.
Co-administration of darunavir and a new pharmacokinetic booster: formulation strategies and evaluation in dogs.
Eur J Pharm Sci
; 41(2): 193-200, 2010 Oct 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-20685614
20.
Development of a long-acting injectable formulation with nanoparticles of rilpivirine (TMC278) for HIV treatment.
Eur J Pharm Biopharm
; 72(3): 502-8, 2009 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-19328850