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1.
Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Circulation
; 148(2): 144-158, 2023 07 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37125593
2.
Evaluating the pharmacokinetics of beclometasone dipropionate/formoterol fumarate/glycopyrronium bromide delivered via pressurised metered-dose inhaler using a low global warming potential propellant.
Pulm Pharmacol Ther
; 85: 102299, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38663512
3.
Safety, Tolerability, and Pharmacokinetics of JNJ-1802, a Pan-serotype Dengue Direct Antiviral Small Molecule, in a Phase 1, Double-Blind, Randomized, Dose-Escalation Study in Healthy Volunteers.
Clin Infect Dis
; 77(6): 857-865, 2023 09 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-37161721
4.
Randomized study of the effect of gadopiclenol, a new gadolinium-based contrast agent, on the QTc interval in healthy subjects.
Br J Clin Pharmacol
; 86(11): 2174-2181, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32302009
5.
Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosis.
Antimicrob Agents Chemother
; 63(12)2019 09 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31570394
6.
Sputum induction for assessment of biomarkers in early respiratory drug developmentâ©.
Int J Clin Pharmacol Ther
; 57(1): 20-23, 2019 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-30520723
7.
A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies.
Invest New Drugs
; 34(2): 184-92, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26792581
8.
Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects.
Br J Clin Pharmacol
; 82(1): 139-48, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26852904
9.
Pharmacokinetics and pharmacodynamics of mibavademab (a leptin receptor agonist): Results from a first-in-human phase I study.
Clin Transl Sci
; 17(4): e13762, 2024 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38591811
10.
Oral administration of GLPG0259, an inhibitor of MAPKAPK5, a new target for the treatment of rheumatoid arthritis: a phase II, randomised, double-blind, placebo-controlled, multicentre trial.
Ann Rheum Dis
; 72(5): 741-4, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23161899
11.
Safety and immunogenicity of the measles vector-based SARS-CoV-2 vaccine candidate, V591, in adults: results from a phase 1/2 randomised, double-blind, placebo-controlled, dose-ranging trial.
EBioMedicine
; 75: 103811, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-35042081
12.
A Randomized, Double-Blind, Placebo-Controlled, Multiple Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of ELX-02 in Healthy Subjects.
Clin Pharmacol Drug Dev
; 10(8): 859-869, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33465285
13.
Pharmacokinetics and Pharmacodynamics of Garetosmab (Anti-Activin A): Results From a First-in-Human Phase 1 Study.
J Clin Pharmacol
; 60(11): 1424-1431, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32557665
14.
Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of ELX-02, a Potential Treatment for Genetic Disorders Caused by Nonsense Mutations, in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 8(8): 984-994, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30650260
15.
Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Filgotinib, a Selective JAK-1 Inhibitor, After Short-Term Treatment of Rheumatoid Arthritis: Results of Two Randomized Phase IIa Trials.
Arthritis Rheumatol
; 69(10): 1949-1959, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28622463
16.
Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds.
Drugs R D
; 5(5): 245-57, 2004.
Artículo
en Inglés
| MEDLINE | ID: mdl-15357624
17.
Pharmacokinetics, safety, and tolerability of GLPG0259, a mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5) inhibitor, given as single and multiple doses to healthy male subjects.
Drugs R D
; 12(3): 141-63, 2012 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22950522
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